First-pass metabolism of ethanol is negligible in rat gastric mucosa

被引：8

作者：

Levitt, MD

Furne, J

DeMaster, E

机构：

[1] Research Service, Vet. Administration Medical Center, Minneapolis, MN

[2] Research Service, Vet. Administration Medical Center, Minneapolis, MN 55417, One Veterans Drive

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1997年 / 21卷 / 02期

关键词：

ethanol; first-pass metabolism; gastric mucosa; alcohol dehydrogenase;

D O I：

10.1111/j.1530-0277.1997.tb03763.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Controversy exists concerning whether first-pass metabolism of imbibed ethanol occurs in the gastric mucosa or liver. We assessed ethanol metabolism in rat gastric mucosa by determining to what extent intact [C-14]ethanol in body water plus hepatic metabolism could account for [C-14]ethanol absorbed from the pylorus-ligated stomach. Intact [C-14]ethanol in systemic body water accounted for 84 +/- 1.9% of the [C-14]ethanol absorbed from the stomach over a 30-min period, Assuming a 15 ml/min hepatic blood flow, the predicted hepatic metabolism of [C-14]ethanol over the 30 min of the study was 18% of the dose. The sum of intact [C-14]ethanol and predicted hepatic metabolism accounted for 100% of the ethanol absorbed from the stomach. We conclude that negligible metabolism of ethanol occurred in the gastric mucosa.

引用

页码：293 / 297

页数：5

共 19 条

[1] Disposition and first-pass metabolism of ethanol in humans: Is it gastric or hepatic and does it depend on gender? [J].