Time domain dielectric spectroscopy study of human cells - II. Normal and malignant white blood cells

被引：167

作者：

Polevaya, Y

Ermolina, I

Schlesinger, M

Ginzburg, BZ

Feldman, Y ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Appl Phys, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Hadassah Med Sch, Hubert H Humphrey Ctr Expt Med & Canc Res, IL-91010 Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Inst Life Sci, Plant Biophys Lab, IL-91904 Jerusalem, Israel

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1999年 / 1419卷 / 02期

关键词：

dielectric property; human lymphocyte suspension; blood cancer; electrode polarization; cell membrane; nuclear envelope;

D O I：

10.1016/S0005-2736(99)00072-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The dielectric properties of human lymphocyte suspensions were studied by time domain dielectric spectroscopy (TDDS). Nine populations of malignant and normal lymphocytes were investigated. Analysis of the dielectric parameters of cell structural parts were performed in the framework of Maxwell-Wagner mixture formula and the double-shell model of cell. The specific capacitance of the cell membranes was estimated by the Hanai-Asami-Koisumi formula. It was shown that the dielectric permittivity, capacitance and conductivity values of cell membranes are higher for normal lymphocytes than for the malignant ones. The difference of the same parameters for normal B- and T-cells is also discussed. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：257 / 271

页数：15

共 37 条

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[Anonymous], 1956, STAT METHODS

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