Expression of interleukin-18 receptor in fibroblast-like synoviocytes

被引：26

作者：

Möller, B

Kessler, U

Rehart, S

Kalina, U

Ottmann, OG

Kaltwasser, JP

Hoelzer, D

Kukoc-Zivojnov, N

机构：

[1] Rheumazentrum Rhein Main, D-60528 Frankfurt, Germany

[2] Univ Frankfurt Klinikum, Med Klin 3, D-6000 Frankfurt, Germany

[3] Goethe Univ Frankfurt, Orthopad Klin, Abt Rheumaorthopadie, D-6000 Frankfurt, Germany

来源：

ARTHRITIS RESEARCH | 2002年 / 4卷 / 02期

关键词：

fibroblast; interleukin-18; receptor; rheumatoid arthritis; synoviocyte;

D O I：

10.1186/ar390

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. We examined the expression of IL-18R alpha-chain and beta-chain and the biologic effects of IL-18 in fibroblast-like synoviocytes (FLS) after long-term culture. The presence of both IL-18R chains was a prerequisite for IL-18 signal transduction in FLS. However, all FLS cultures studied were either resistant or barely responsive to IL-18 stimulation as regards cell proliferation, expression of adhesion molecules ICAM-1 and vascular cell adhesion molecule (VCAM)-1, and the release of interstitial collagenase and stromelysin, IL-6 and IL-8, prostaglandin E-2, or nitric oxide. We conclude that the presence of macrophages or IL-1BR(+) T cells that can respond directly to IL-18 is essential for the proinflammatory effects of IL-18 in synovitis in RA.

引用

页码：139 / 144

页数：6

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