Convenient Synthesis and Antimicrobial Activity of New 3-Substituted 5-(Benzofuran-2-yl)-pyrazole Derivatives

被引：70

作者：

Abdel-Wahab, Bakr F. ^{[1
]}

Abdel-Aziz, Hatem A. ^{[1
]}

Ahmed, Essam M. ^{[2
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Giza, Egypt

[2] Natl Res Ctr, Nat & Microbial Prod Chem Dept, Giza, Egypt

来源：

ARCHIV DER PHARMAZIE | 2008年 / 341卷 / 11期

关键词：

2-Acetylbenzofuran; Acid hydrazides; Antimicrobial activity; Bis-pyrazoles; Ethyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate; 4-Thiazolidinones;

D O I：

10.1002/ardp.200800119

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reaction of ethyl 4-(benzofuran-2-yl)-2,4-dioxobutanoate 2 with two moles of hydrazine hydrate afforded 5-(benzofuran-2-yl)-1H-pyrazole-3- carbohydrazide 4a, while its reaction with equimolar amount of phenylhydrazine gave ester 3b which then converted to 5-(benzofuran-2-yl)-1- phenyl-1H-pyrazole-3-carbohydrazide 4b. Various new compounds such as imides 5 and 6, acyl hydrazones 7 and 8, bi-pyrazoles 9-12, and 1,3-thiazole derivatives 14 and 15 were prepared from carbohydrazide derivatives 4a, b. The new compounds are tested for their antimicrobial activity. Compounds 2, 5, 7, and 8 showed antifungal activities against C. albicans. Also, compounds 2, 6, 8, and 15 showed antibacterial activities.

引用

页码：734 / 739

页数：6

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