Synthesis and study of water-soluble chitosan-O-poly(ethylene glycol) graft copolymers

被引：120

作者：

Gorochovceva, N ^{[1
]}

Makuska, R ^{[1
]}

机构：

[1] Vilnius Univ, Dept Polymer Chem, LT-2006 Vilnius, Lithuania

来源：

EUROPEAN POLYMER JOURNAL | 2004年 / 40卷 / 04期

关键词：

chitosan; poly(ethylene glycol); O-PEGylated chitosan; water soluble; graft copolymer; viscosity;

D O I：

10.1016/j.eurpolymj.2003.12.005

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Novel chitosan-O-poly(ethylene glycol) graft copolymers were synthesized. Etherification of N-phthaloyl chitosan by poly(ethylene glycol) monomethyl ether (MPEG) iodide was carried out in dimethylformamide in the presence of silver oxide. Varying the ratio of MPEG iodide to chitosan, different degree of O-substitution of MPEG to monosaccharide residue of chitosan (5-197%) was obtained. Chemical structure of the new chitosan derivatives was confirmed using FTIR spectroscopy and analysis of functional groups. O-PEGylated chitosans are soluble in water and aqueous solutions of wide pH range. Reduced viscosity of aqueous solutions of the graft copolymers is extremely low and similar to that of MPEG-2000. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：685 / 691

页数：7

共 14 条

[1]

AIBA S, 1993, MAKROMOL CHEM, V194, P65

[2]

DOMSZY JG, 1985, MAKROMOL CHEM, V186, P1671

[3]

Harris J.M., 1992, Polyethylene Glycol: Chemistry and Biological Applications

[4] SYNTHESIS AND CHARACTERIZATION OF POLY(ETHYLENE GLYCOL) DERIVATIVES [J].

HARRIS, JM ;

STRUCK, EC ;

CASE, MG ;

PALEY, MS ;

VANALSTINE, JM ;

BROOKS, DE .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 1984, 22 (02) :341-352

[5] Controlled functionalization of the polysaccharide chitin [J].

Kurita, K .

PROGRESS IN POLYMER SCIENCE, 2001, 26 (09) :1921-1971

[6]

Loudon G. M., 2002, ORGANIC CHEM

[7] REACTIONS OF CHITOSAN .4. PREPARATION OF ORGANOSOLUBLE DERIVATIVES OF CHITOSAN [J].

MOORE, GK ;

ROBERTS, GAF .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 1982, 4 (04) :246-249

[8] A colorimetric assay for estimation of polyethylene glycol and polyethylene glycolated protein using ammonium ferrothiocyanate [J].

Nag, A ;

Mitra, G ;

Ghosh, PC .

ANALYTICAL BIOCHEMISTRY, 1996, 237 (02) :224-231

[9] CHEMOSPECIFIC MANIPULATIONS OF A RIGID POLYSACCHARIDE - SYNTHESES OF NOVEL CHITOSAN DERIVATIVES WITH EXCELLENT SOLUBILITY IN COMMON ORGANIC-SOLVENTS BY REGIOSELECTIVE CHEMICAL MODIFICATIONS [J].

NISHIMURA, SI ;

KOHGO, O ;

KURITA, K ;

KUZUHARA, H .

MACROMOLECULES, 1991, 24 (17) :4745-4748

[10] Aggregation phenomenon of PEG-grafted chitosan in aqueous solution [J].

Ouchi, T ;

Nishizawa, H ;

Ohya, Y .

POLYMER, 1998, 39 (21) :5171-5175

← 1 2 →