Expression of CD26/dipeptidyl peptidase IV in adult T cell leukemia/lymphoma (ATLL)

被引：19

作者：

Kondo, S

Kotani, T

Tamura, K

Aratake, Y

Uno, H

Tsubouchi, H

Inoue, S

Niho, Y

Ohtaki, S

机构：

[1] MIYAZAKI MED COLL, DEPT LAB MED, MIYAZAKI 88916, JAPAN

[2] MIYAZAKI MED COLL, DIV BLOOD TRANSFUS, MIYAZAKI 88916, JAPAN

[3] MIYAZAKI MED COLL, CENT LAB CLIN INVEST, MIYAZAKI 88916, JAPAN

[4] MIYAZAKI PREFECTURAL HOSP, MIYAZAKI, JAPAN

[5] MIYAZAKI MED COLL, DEPT DERMATOL, MIYAZAKI 88916, JAPAN

[6] KYUSHU UNIV, FAC MED, DEPT INTERNAL MED 1, FUKUOKA 812, JAPAN

来源：

LEUKEMIA RESEARCH | 1996年 / 20卷 / 04期

关键词：

ATLL; CD26; HTLV-I;

D O I：

10.1016/0145-2126(95)00159-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The association of CD26/dipeptidyl peptidase IV (DPPIV) and human T lymphotropic virus type I (HTLV-I) was studied by two approaches. First, we examined the expression of CD26 in peripheral blood mononuclear cells (PBMC) from the patients with adult T cell leukemia/lymphoma (ATLL), an HTLV-I-related malignancy. The expression of CD26 on the surface of PBMC was decreased in all 20 patients with ATLL compared with those from normal individuals (P<0.01) and the expression of the CD26 gene transcript was not detectable in seven out of eight patients with ATLL. Then we compared the quantity of viral DNA in CD26-negative (CD26-) and CD26-positive (CD26+) cells obtained from 17 HTLV-I healthy carriers by using a polymerase chain reaction method. The CD26- cells had a higher copy number of viral DNA than CD26+ cells. These findings indicate that HTLV-I has in vivo tropism to CD26- cells, suggesting that some phenotypes of ATLL cells reflect the in vivo cellular tropism of HTLV-I. (C) 1996 Published by Elsevier Science Ltd.

引用

页码：357 / 363

页数：7

共 35 条

[1] BLAZQUEZ MV, 1992, J IMMUNOL, V149, P3073
[2] BRODER CC, 1994, SCIENCE, V264, P1156, DOI 10.1126/science.7909959
[3] T-CELL ACTIVATION ANTIGEN, CD26, AS A COFACTOR FOR ENTRY OF HIV IN CD4+ CELLS
CALLEBAUT, C
KRUST, B
JACOTOT, E
HOVANESSIAN, AG
[J]. SCIENCE, 1993, 262 (5142) : 2045 - 2050
[4] DANG NH, 1990, J IMMUNOL, V145, P3963
[5] ENSSLE KH, 1990, CLIN EXP IMMUNOL, V79, P409
[6] TRIGGERING OF THE LETHAL HIT IN HUMAN CYTOTOXIC LYMPHOCYTES-T - A FUNCTIONAL-ROLE FOR A 103-KDA T-CELL-SPECIFIC ACTIVATION ANTIGEN
FLEISCHER, B
SCHENDEL, DJ
VONSTELDERN, D
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1986, 16 (07) : 741 - 746
[7] CD26 - A SURFACE PROTEASE INVOLVED IN T-CELL ACTIVATION
FLEISCHER, B
[J]. IMMUNOLOGY TODAY, 1994, 15 (04): : 180 - 184
[8] FOX DA, 1984, J IMMUNOL, V133, P1250
[9] C-FOS PROMOTER TRANS-ACTIVATION BY THE TAX1 PROTEIN OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I
FUJII, M
SASSONECORSI, P
VERMA, IM
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (22) : 8526 - 8530
[10] HAFLER DA, 1986, J IMMUNOL, V137, P414

← 1 2 3 4 →