Insulin-like growth factor-I: Compartmentalization within the somatotropic axis?

被引：23

作者：

Butler, AA ^{[1
]}

Yakar, S

LeRoith, D

机构：

[1] Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA

[2] NIDDKD, Clin Endocrinol Branch, NIH, Bethesda, MD 20892 USA

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2002年 / 17卷

关键词：

D O I：

10.1152/nips.01351.2001

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.

引用

页码：82 / 85

页数：4

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