Emotional reactivity in mice, a case of nongenetic heredity?

Nongenetic heredity cases have been described in man, as well as in animals, and relationships between parents and offspring seem to play an important role in this transmission. In mice, mothering type could be nongenetically heritable by a latent learning close to mechanism. As mothering style clearly influences emotional reactivity, this reactivity could be nongenetically transmitted over generations. To clarify this question, the mother's influence on adult offspring reactivity must be established (whatever its basis, genetic, social or other). Thus, two reciprocal F1 hybrids (CB6 from a BALB/c mother and B6C from a C57BL/6 mother) have been compared using an ethological analysis in animal tests of emotional reactivity such as the free exploration paradigm and the light/dark box. First results show a sharp influence of the mother's strain and that suggests an effect of mothering style. The offspring from C57BL/6 mothers display less reactivity in the free exploration paradigm than the offspring from BALB/c mothers. In the light/dark box, no difference has been found between the two hybrids. Moreover, the mother's influence is greater in males than in females. (C) 2001 Elsevier Science Inc. All rights reserved.