Enhanced delivery of baicalein using cinnamaldehyde cross-linked chitosan nanoparticle inducing apoptosis

被引：58

作者：

Babu, Varukattu Nipun ^{[1
]}

Kannan, Soundarapandian ^{[1
]}

机构：

[1] Bharathiar Univ, Prote & Mol Cell Physiol Lab, Dept Zool, Sch Life Sci, Coimbatore 641046, Tamil Nadu, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 05期

关键词：

Chitosan; Baicalein; Cinnamaldehyde; Apoptosis; CANCER CELL-LINES; IN-VITRO; INHIBITION; VIVO; GLUTARALDEHYDE; PROLIFERATION; FLAVONOIDS; TOXICITY; ESTROGEN; CARRIERS;

D O I：

10.1016/j.ijbiomac.2012.08.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The chitosan (CS) nanoparticles, baicalein loaded chitosan nanoparticles were prepared by crosslinking method in a W/O emulsion system, using cinnamaldehyde as crosslinking agent. The FT-IR result showed the binding of anticancer compound baicalein to the nanoparticles. The TEM analysis revealed that the particles are spherical in nature. Zeta potential revealed negative charge of the particles. Ultraviolet spectrum analysis described that higher loading efficiency and encapsulation efficiency as 9.1% and 97.2%, respectively. In vitro baicalein release profile demonstrated the delivery of baicalein from the CS nanoparticles is a two stage process. RT-PCR and cell culture was carried out accordingly. (C) 2012 Elsevier B.V. All rights reserved.

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页码：1103 / 1108

页数：6

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