Magnetization transfer imaging in multiple sclerosis treated with alemtuzumab

被引：30

作者：

Button, Tom ^{[1
]}

Altmann, Dan ^{[2
]}

Tozer, Dan ^{[3
]}

Dalton, Catherine ^{[3
]}

Hunter, Kelvin ^{[3
]}

Compston, Alastair ^{[1
]}

Coles, Alasdair ^{[1
]}

Miller, David ^{[3
]}

机构：

[1] Univ Cambridge, Cambridge CB2 2QQ, England

[2] London Sch Hyg & Trop Med, London WC1, England

[3] UCL Inst Neurol, London, England

来源：

MULTIPLE SCLEROSIS JOURNAL | 2013年 / 19卷 / 02期

关键词：

magnetization transfer; multiple sclerosis; alemtuzumab;

D O I：

10.1177/1352458512444915

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

The magnetization transfer ratio reflects the integrity of tissue structure, including myelination and axonal density. Mean magnetization transfer ratio fell in 18 untreated patients with multiple sclerosis both in normal appearing grey (-0.25 pu/year, p < 0.001) and white matter (-0.12 pu/year, p = 0.004). Conversely, mean magnetization transfer ratio was stable in 20 alemtuzumab-treated patients (grey matter: -0.01 pu/year, p = 0.87; white matter: -0.02 pu/year, p = 0.51). The gradient difference in grey matter was 0.25 pu/year < 0.001) after age-adjustment. These data suggest that in multiple sclerosis alemtuzumab protects against tissue damage in normal-appearing grey matter, perhaps by preventing new lesion formation.

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收藏

页码：241 / 244

页数：4

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