sst5 somatostatin receptor mRNA induction by mitogenic activation of human T-lymphocytes

被引：23

作者：

El Ghamrawy, C ^{[1
]}

Rabourdin-Combe, C ^{[1
]}

Krantic, S ^{[1
]}

机构：

[1] Ecole Normale Super Lyon, Biol Cellulaire & Mol Lab, UMR 49, F-69364 Lyon 07, France

来源：

PEPTIDES | 1999年 / 20卷 / 03期

关键词：

expression pattern of SRIF receptor subtypes; TPA/PHA; activation of T-lymphocytes;

D O I：

10.1016/S0196-9781(99)00036-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SRIF has neuro-immunomodulatory actions on immune cells, including T-lymphocytes. Molecular mechanisms involved in these actions were studied by RT-PCR analysis of SRIF receptor expression in resting and mitogen-activated human T-lymphocytes. Our results point to the mitogen-associated induction of sst5 receptor subtype. Conversely, sst3 receptor appears constitutively expressed in both activity states. Assessment of biologic actions of SRIF14 in activated T-lymphocytes indicates that, in nanomolar concentration range, this peptide moderately inhibits mitogen-induced IL-2 secretion. Nevertheless, T-lymphocyte proliferation is not inhibited in the presence of SRIF14 but is even slightly increased. Altogether these data suggest a complex mechanism of SRIF neuro-immunomodulatory actions. (C) 1989 Elsevier Science Inc. All rights reserved.

引用

页码：305 / 311

页数：7

共 33 条

[1] Somatostatin antisense oligodeoxynucleotide-mediated stimulation of lymphocyte proliferation in culture [J].

Aguila, MC ;

Rodriguez, AM ;

AguilaMansilla, HN ;

Lee, WT .

ENDOCRINOLOGY, 1996, 137 (05) :1585-1590

[2] MOLECULAR-BIOLOGY OF SOMATOSTATIN RECEPTORS [J].

BELL, GI ;

REISINE, T .

TRENDS IN NEUROSCIENCES, 1993, 16 (01) :34-38

[3] Immune-neuro-endocrine interactions: Facts and hypotheses [J].

Besedovsky, HO ;

DelRey, A .

ENDOCRINE REVIEWS, 1996, 17 (01) :64-102

[4] IDENTIFICATION OF HUMAN MONONUCLEAR LEUKOCYTES BEARING RECEPTORS FOR SOMATOSTATIN AND GLUCAGON [J].

BHATHENA, SJ ;

LOUIE, J ;

SCHECHTER, GP ;

REDMAN, RS ;

WAHL, L ;

RECANT, L .

DIABETES, 1981, 30 (02) :127-131

[5]

CANTRELL DA, 1989, J IMMUNOL, V142, P1626

[6]

Cardoso A, 1998, J CELL BIOCHEM, V68, P62, DOI 10.1002/(SICI)1097-4644(19980101)68:1<62::AID-JCB6>3.0.CO

[7]

2-U

[8]

ELLIOTT DE, 1994, J IMMUNOL, V153, P1180

[9] SOMATOSTATIN IN THE CENTRAL-NERVOUS-SYSTEM - PHYSIOLOGY AND PATHOLOGICAL MODIFICATIONS [J].

EPELBAUM, J .

PROGRESS IN NEUROBIOLOGY, 1986, 27 (01) :63-100

[10] EFFECTS OF SOMATOSTATIN ON HUMAN INTESTINAL LAMINA PROPRIA LYMPHOCYTES - MODULATION OF LYMPHOCYTE-ACTIVATION [J].

FAIS, S ;

ANNIBALE, B ;

BOIRIVANT, M ;

SANTORO, A ;

PALLONE, F ;

DELLEFAVE, G .

JOURNAL OF NEUROIMMUNOLOGY, 1991, 31 (03) :211-219

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