Genome-wide meta-analysis identifies new susceptibility loci for migraine

被引：301

作者：

Anttila, Verneri ^{[1
,2
,3
,4
,5
]}

Winsvold, Bendik S. ^{[1
,6
,7
]}

Gormley, Padhraig ^{[1
]}

Kurth, Tobias ^{[4
,8
,9
,10
]}

Bettella, Francesco ^{[11
]}

McMahon, George ^{[12
]}

Kallela, Mikko ^{[13
]}

Malik, Rainer ^{[14
]}

de Vries, Boukje ^{[15
]}

Terwindt, Gisela ^{[16
]}

Medland, Sarah E. ^{[17
]}

Todt, Unda ^{[18
]}

McArdle, Wendy L. ^{[12
]}

Quaye, Lydia ^{[19
]}

Koiranen, Markku ^{[20
,21
]}

Ikram, M. Arfan ^{[22
,23
,24
]}

Lehtimaki, Terho ^{[25
,26
]}

Stam, Anine H. ^{[16
]}

Ligthart, Lannie ^{[27
,28
]}

Wedenoja, Juho ^{[29
]}

Dunham, Ian ^{[30
]}

Neale, Benjamin M. ^{[3
,4
,5
]}

Palta, Priit ^{[1
,2
]}

Hamalainen, Eija ^{[1
,2
]}

Schuerks, Markus ^{[31
]}

Rose, Lynda M. ^{[4
,10
]}

Buring, Julie E. ^{[4
,10
]}

Ridker, Paul M. ^{[4
,10
,32
]}

Steinberg, Stacy ^{[11
]}

Stefansson, Hreinn ^{[11
]}

Jakobsson, Finnbogi ^{[33
]}

Lawlor, Debbie A. ^{[12
]}

Evans, David M. ^{[12
]}

Ring, Susan M. ^{[12
]}

Farkkila, Markus ^{[13
]}

Artto, Ville ^{[13
]}

Kaunisto, Mari A. ^{[2
,34
]}

Freilinger, Tobias ^{[14
,35
]}

Schoenen, Jean ^{[36
,37
]}

Frants, Rune R. ^{[15
]}

Pelzer, Nadine ^{[16
]}

Weller, Claudia M. ^{[15
]}

Zielman, Ronald ^{[16
]}

Heath, Andrew C. ^{[38
]}

Madden, Pamela A. F. ^{[38
]}

Montgomery, Grant W. ^{[17
]}

Martin, Nicholas G. ^{[17
]}

Borck, Guntram ^{[18
]}

Goebel, Hartmut ^{[39
]}

Heinze, Axel ^{[39
]}

机构：

[1] Wellcome Trust Sanger Inst, Cambridge, England

[2] Univ Helsinki, FIMM, Helsinki, Finland

[3] Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA USA

[6] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[7] Univ Oslo, Oslo, Norway

[8] INSERM, Neuroepidemiol U708, Bordeaux, France

[9] Univ Bordeaux, Bordeaux, France

[10] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA

[11] deCODE Genet, Reykjavik, Iceland

[12] Univ Bristol, Univ Bristol Med Res Council MRC Integrat Epidemi, Bristol, Avon, England

[13] Univ Helsinki, Cent Hosp, Dept Neurol, Helsinki, Finland

[14] Univ Munich, Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany

[15] Leiden Univ, Dept Human Genet, Med Ctr, NL-2300 RA Leiden, Netherlands

[16] Leiden Univ, Med Ctr, Dept Neurol, Leiden, Netherlands

[17] Queensland Inst Med Res, Brisbane, Qld 4006, Australia

[18] Univ Ulm, Inst Human Genet, D-89069 Ulm, Germany

[19] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

[20] Univ Oulu, Inst Hlth Sci, Oulu, Finland

[21] Oulu Univ Hosp, Unit Primary Care, Oulu, Finland

[22] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands

[23] Erasmus Univ, Med Ctr, Dept Radiol, Rotterdam, Netherlands

[24] Erasmus Univ, Med Ctr, Dept Neurol, Rotterdam, Netherlands

[25] Fimlab Labs, Dept Clin Chem, Tampere, Finland

[26] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland

[27] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

[28] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands

[29] Univ Helsinki, Dept Publ Hlth, Hjelt Inst, Helsinki, Finland

[30] European Mol Biol Lab, European Bioinformat Inst, Cambridge, England

[31] Univ Hosp Essen, Dept Neurol, Essen, Germany

[32] Harvard Univ, Sch Med, Dept Epidemiol, Boston, MA USA

[33] Landspitali Univ Hosp, Dept Neurol, Reykjavik, Iceland

[34] Folkhalsan Res Ctr, Helsinki, Finland

[35] Klinikum Univ Munchen, Dept Neurol, Munich, Germany

[36] Univ Liege, Dept Neurol, Headache Res Unit, Liege, Belgium

[37] Univ Liege, GIGA Neurosci, Liege, Belgium

[38] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[39] Kiel Pain & Headache Ctr, Kiel, Germany

[40] Univ Hosp Oulu, Dept Clin Sci Obstet & Gynecol, Oulu, Finland

[41] Univ Oulu, Med Res Ctr, Oulu, Finland

[42] Natl Inst Hlth & Welf, Dept Children Young People & Families, Helsinki, Finland

[43] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands

[44] Univ Bonn, Life & Brain Ctr, Dept Genom, Bonn, Germany

[45] Univ Bonn, Inst Human Genet, Bonn, Germany

[46] Max Planck Inst Psychiat, D-80804 Munich, Germany

[47] Munich Cluster Syst Neurol SyNergy, Munich, Germany

[48] Univ Kiel, Inst Clin Mol Biol, Kiel, Germany

[49] Univ Kiel, Dept Internal Med 1, Kiel, Germany

[50] Helmholtz Ctr Munich, Inst Human Genet, Neuherberg, Germany

来源：

NATURE GENETICS | 2013年 / 45卷 / 08期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

TRANSFORMING-GROWTH-FACTOR; DOWN-REGULATION; ASSOCIATION; EXPRESSION; PROTEIN; FAMILY; MUTATIONS; LEWIS(X); GENES;

D O I：

10.1038/ng.2676

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P < 5 x 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

引用

页码：912 / U255

页数：8

共 52 条

[1] Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins
Allen, PB
Greenfield, AT
Svenningsson, P
Haspeslagh, DC
Greengard, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (18) : 7187 - 7192
[2] Genetic Mapping in Human Disease
Altshuler, David
Daly, Mark J.
Lander, Eric S.
[J]. SCIENCE, 2008, 322 (5903) : 881 - 888
[3] Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
Anttila, Verneri
Stefansson, Hreinn
Kallela, Mikko
Todt, Unda
Terwindt, Gisela M.
Calafato, M. Stella
Nyholt, Dale R.
Dimas, Antigone S.
Freilinger, Tobias
Mueller-Myhsok, Bertram
Artto, Ville
Inouye, Michael
Alakurtti, Kirsi
Kaunisto, Mari A.
Haemaelaeinen, Eija
de Vries, Boukje
Stam, Anine H.
Weller, Claudia M.
Heinze, Axel
Heinze-Kuhn, Katja
Goebel, Ingrid
Borck, Guntram
Goebel, Hartmut
Steinberg, Stacy
Wolf, Christiane
Bjoernsson, Asgeir
Gudmundsson, Gretar
Kirchmann, Malene
Hauge, Anne
Werge, Thomas
Schoenen, Jean
Eriksson, Johan G.
Hagen, Knut
Stovner, Lars
Wichmann, Erich
Meitinger, Thomas
Alexander, Michael
Moebus, Susanne
Schreiber, Stefan
Aulchenko, Yurii S.
Breteler, Monique M. B.
Uitterlinden, Andre G.
Hofman, Albert
van Duijn, Cornelia M.
Tikka-Kleemola, Paevi
Vepsaelaeinen, Salli
Lucae, Susanne
Tozzi, Federica
Muglia, Pierandrea
Barrett, Jeffrey
[J]. NATURE GENETICS, 2010, 42 (10) : 869 - +
[4] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING
BENJAMINI, Y
HOCHBERG, Y
[J]. JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) : 289 - 300
[5] Downregulation of transforming growth factor, beta receptor 2 and Notch signaling pathway in human abdominal aortic aneurysm
Biros, Erik
Walker, Philip J.
Nataatmadja, Maria
West, Malcolm
Golledge, Jonathan
[J]. ATHEROSCLEROSIS, 2012, 221 (02) : 383 - 386
[6] A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
Bolstad, BM
Irizarry, RA
Åstrand, M
Speed, TP
[J]. BIOINFORMATICS, 2003, 19 (02) : 185 - 193
[7] The Nogo-66 receptor family in the intact and diseased CNS
Borrie, Sarah C.
Baeumer, Bastian E.
Bandtlow, Christine E.
[J]. CELL AND TISSUE RESEARCH, 2012, 349 (01) : 105 - 117
[8] Annotation of functional variation in personal genomes using RegulomeDB
Boyle, Alan P.
Hong, Eurie L.
Hariharan, Manoj
Cheng, Yong
Schaub, Marc A.
Kasowski, Maya
Karczewski, Konrad J.
Park, Julie
Hitz, Benjamin C.
Weng, Shuai
Cherry, J. Michael
Snyder, Michael
[J]. GENOME RESEARCH, 2012, 22 (09) : 1790 - 1797
[9] Genome-wide association study reveals three susceptibility loci for common migraine in the general population
Chasman, Daniel I.
Schuerks, Markus
Anttila, Verneri
de Vries, Boukje
Schminke, Ulf
Launer, Lenore J.
Terwindt, Gisela M.
van den Maagdenberg, Arn M. J. M.
Fendrich, Konstanze
Voelzke, Henry
Ernst, Florian
Griffiths, Lyn R.
Buring, Julie E.
Kallela, Mikko
Freilinger, Tobias
Kubisch, Christian
Ridker, Paul M.
Palotie, Aarno
Ferrari, Michel D.
Hoffmann, Wolfgang
Zee, Robert Y. L.
Kurth, Tobias
[J]. NATURE GENETICS, 2011, 43 (07) : 695 - U116
[10] INJECTION OF THE CAMP-RESPONSIVE ELEMENT INTO THE NUCLEUS OF APLYSIA SENSORY NEURONS BLOCKS LONG-TERM FACILITATION
DASH, PK
HOCHNER, B
KANDEL, ER
[J]. NATURE, 1990, 345 (6277) : 718 - 721

← 1 2 3 4 5 6 →