Man as living bioreactor:: Fate of an exogenously prepared customized tissue-engineered mandible

被引：172

作者：

Warnke, PH

Wiltfang, J

Springer, I

Acil, Y

Bolte, H

Kosmahl, M

Russo, PAJ

Sherry, E

Lützen, U

Wolfart, S

Terheyden, H

机构：

[1] Univ Kiel, Dept Oral & Maxillofacial Surg, D-24105 Kiel, Germany

[2] Univ Kiel, Dept Diagnost Radiol, D-24105 Kiel, Germany

[3] Univ Kiel, Dept Pathol, D-24105 Kiel, Germany

[4] Univ Sydney, Royal N Shore Hosp, Sydney, NSW 2006, Australia

[5] Univ Kiel, Dept Nucl Med, D-24098 Kiel, Germany

[6] Univ Kiel, Dept Prosthodont & Mat Res, D-24098 Kiel, Germany

来源：

BIOMATERIALS | 2006年 / 27卷 / 17期

关键词：

in vivo tissue engineering; bone regeneration; replacement; bioreactor; mandible reconstruction; BMP;

D O I：

10.1016/j.biomaterials.2006.01.050

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In 2004, we reported it novel method of repairing a human mandible by in vivo tissue engineering. The patient served as his own bioreactor as the exogenously prepared customized mandible replacement was grown inside his latissimus dorsi muscle prior to transplantation to repair the existing defect. Our technique was developed through extensive experience with an animal model. We describe our and the patient's experiences with this procedure. We give details to the benefits and limitations of this technique as it stands and outline issues that should be addressed in future human clinical trials. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3163 / 3167

页数：5

共 8 条

[1] Reconstruction of human mandible by tissue engineering [J].