Increased cell-free DNA in plasma of patients with metastatic spread in prostate cancer

被引：82

作者：

Jung, K

Stephan, C

Lewandowski, M

Klotzek, S

Jung, M

Kristiansen, G

Lein, M

Loening, SA

Schnorr, D

机构：

[1] Humboldt Univ, Univ Hosp Charite, Dept Urol, D-10098 Berlin, Germany

[2] Humboldt Univ, Univ Hosp Charite, Dept Pathol, D-10098 Berlin, Germany

来源：

CANCER LETTERS | 2004年 / 205卷 / 02期

关键词：

prostate cancer; benign prostatic hyperplasia; plasma DNA; metastasis; survival;

D O I：

10.1016/j.canlet.2003.11.023

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We compared the plasma DNA concentrations in patients with different prostate cancer (PCa) stages and with benign prostate hyperplasia (BPH) and in healthy persons. Patients with localized cancer had DNA plasma within the reference interval. Increased plasma DNA was found in patients with lymph node and distant metastases and also in BPH. The association between plasma DNA and the survival time was similarly strong as with prostate-specific antigen. It can be concluded that plasma DNA has a limited validity as metastatic marker in PCa patients but follow-up studies combined with the investigation of tumor-related characteristics of plasma DNA would be reasonable. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：173 / 180

页数：8

共 30 条

[1] Circulating nucleic acids in plasma and serum as a noninvasive investigation for cancer: Time for large-scale clinical studies? [J].