Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen

被引：55

作者：

Capitano, B

Potoski, BA

Husain, S

Zhang, SM

Paterson, DL

Studer, SM

McCurry, KR

Venkataramanan, R

机构：

[1] Univ Pittsburgh, Sch Pharm, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Div Infect Dis, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Div Pulm & Crit Care Med, Pittsburgh, PA 15261 USA

[4] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15261 USA

[5] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA 15261 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 05期

关键词：

D O I：

10.1128/AAC.50.5.1878-1880.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Voriconazole penetrated well into the pulmonary epithelial lining fluid (ELF) in lung transplant patients receiving oral prophylaxis. The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/- 8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted.

引用

页码：1878 / 1880

页数：3

共 18 条

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