Effect of Jianweiyuyang granule on gastric ulcer recurrence and expression of VEGF mRNA in the healing process of gastric ulcer in rats

被引：15

作者：

Dai, Xing-Ping ^{[1
]}

Li, Jia-Bang ^{[1
]}

Liu, Zhao-Qian ^{[3
]}

Ding, Xiang ^{[2
]}

Huang, Cheng-Hui ^{[1
]}

Zhou, Bing ^{[1
]}

机构：

[1] Cent S Univ, Inst Integrated Tradit Chinese & Western Med, Changsha 410078, Hunan, Peoples R China

[2] Cent S Univ, Dept Gastroenterol, Xiangya Hosp, Changsha 410078, Hunan, Peoples R China

[3] Cent S Univ, Inst Clin Pharmacol, Xiangya Sch Med, Changsha 410078, Hunan, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2005年 / 11卷 / 35期

关键词：

Jianweiyuyang granule; Gastric ulcer; VEGF mRNA;

D O I：

10.3748/wjg.v11.i35.5480

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To investigate the effect of Jianweiyuyang (JWYY) granule on gastric ulcer recurrence and its mechanism in the treatment of gastric ulcer in rats. METHODS: Gastric ulcer in rats was induced according to Okeba's method with minor modification and the recurrence model was induced by IL-1 beta. The expression of vascular endothelial growth factor mRNA (VEGF mRNA) was examined by reverse transcription polymerase chain reaction in gastric ulcer and microvessel density (MVD) adjacent to the ulcer margin was examined by immunohistochemistry. RESULTS: MVD was higher in the JWYY treatment group (14.0 +/- 2.62) compared with the normal, model and ranitidine treatment groups (2.2 +/- 0.84, 8.8 +/- 0.97, 10.4 +/- 0.97) in rats (P<0.01). The expression level of VEGF mRNA in gastric tissues during the healing process of JWYY treatment group rats significantly increased compared with other groups (normal group: 0.190 +/- 0.019, model group: 0.642 +/- 0.034, ranitidine group: 0.790 +/- 0.037, P<0.01). CONCLUSION: JWYY granules can stimulate angiogenesis and enhance the expression of VEGF mRNA in gastric ulcer rats. This might be the mechanism for JWYY accelerating the ulcer healing, and preventing the recurrence of gastric ulcer. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

引用

页码：5480 / 5484

页数：5

共 18 条

[1]

Esophageal ulceration triggers expression of hypoxia-inducible factor-1α and activates vascular endothelial growth factor gene -: Implications for angiogenesis and ulcer healing [J].