Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems

被引:175
作者
Alagarsamy, S
Marino, MJ
Rouse, ST
Gereau, RW
Heinemann, SF
Conn, PJ
机构
[1] Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA
[2] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA
[3] Salk Inst Biol Studies, Mol Neurobiol Lab, La Jolla, CA 92037 USA
关键词
D O I
10.1038/6338
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The metabotropic glutamate receptor, mGluR5, has a critical role in induction of NMDA-receptor-dependent forms of synaptic plasticity and excitotoxicity. This is likely mediated by a reciprocal positive-feedback interaction between these two glutamate receptor subtypes in which activation of mGluR5 potentiates NMDA receptor currents and NMDA receptor activation potentiates mGluR5-mediated responses. We have investigated the mechanism by which NMDA receptor activation modulates mGluR5 function and find evidence that this response is mediated by activation of a protein phosphatase and a resultant dephosphorylation of protein kinase C phosphorylation sites on mGluR5. This form of neuromodulation may be important in a number of normal and pathological processes that involve activation of the NMDA receptor.
引用
收藏
页码:234 / 240
页数:7
相关论文
共 39 条
[1]   Receptor-mediated activation of protein kinase C in hippocampal long-term potentiation: Facts, problems and implications [J].
Angenstein, F ;
Staak, S .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1997, 21 (03) :427-454
[2]   QUISQUALATE METABOTROPIC RECEPTORS MODULATE NMDA CURRENTS AND FACILITATE INDUCTION OF LONG-TERM POTENTIATION THROUGH PROTEIN-KINASE-C [J].
ANIKSZTEJN, L ;
OTANI, S ;
BENARI, Y .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1992, 4 (06) :500-505
[3]   A TRANSIENT CALCIUM-DEPENDENT CHLORIDE CURRENT IN THE IMMATURE XENOPUS OOCYTE [J].
BARISH, ME .
JOURNAL OF PHYSIOLOGY-LONDON, 1983, 342 (SEP) :309-325
[4]   STUDIES ON THE ROLE OF METABOTROPIC GLUTAMATE RECEPTORS IN LONG-TERM POTENTIATION - SOME METHODOLOGICAL CONSIDERATIONS [J].
BORTOLOTTO, ZA ;
BASHIR, ZI ;
DAVIES, CH ;
TAIRA, T ;
KAILA, K ;
COLLINGRIDGE, GL .
JOURNAL OF NEUROSCIENCE METHODS, 1995, 59 (01) :19-24
[5]   FUNCTIONAL DIVERSITY OF CENTRAL GLUTAMATE SYNAPSES - PRE-SYNAPTIC AND POSTSYNAPTIC MECHANISMS [J].
BRODIN, L ;
SHUPLIAKOV, O .
ACTA PHYSIOLOGICA SCANDINAVICA, 1994, 150 (01) :1-10
[6]   ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS COUPLED TO INOSITOL PHOSPHOLIPID HYDROLYSIS AMPLIFIES NMDA-INDUCED NEURONAL DEGENERATION IN CULTURED CORTICAL-CELLS [J].
BRUNO, V ;
COPANI, A ;
KNOPFEL, T ;
KUHN, R ;
CASABONA, G ;
DELLALBANI, P ;
CONDORELLI, DF ;
NICOLETTI, F .
NEUROPHARMACOLOGY, 1995, 34 (08) :1089-1098
[7]   MODULATORY EFFECTS OF NMDA ON PHOSPHOINOSITIDE RESPONSES EVOKED BY THE METABOTROPIC GLUTAMATE-RECEPTOR AGONIST 1S,3R-ACPD IN NEONATAL RAT CEREBRAL-CORTEX [J].
CHALLISS, RAJ ;
MISTRY, R ;
GRAY, DW ;
NAHORSKI, SR .
BRITISH JOURNAL OF PHARMACOLOGY, 1994, 112 (01) :231-239
[8]  
CIABARRA AM, 1995, J NEUROSCI, V15, P6498
[9]   MEMORIES OF NMDA RECEPTORS AND LTP [J].
COLLINGRIDGE, GL ;
BLISS, TVP .
TRENDS IN NEUROSCIENCES, 1995, 18 (02) :54-56
[10]   INDIRECT POTENTIATION OF SYNAPTIC TRANSMISSION BY METABOTROPIC GLUTAMATE RECEPTORS IN THE RAT HIPPOCAMPAL SLICE [J].
COLLINS, DR ;
SCOLLON, JM ;
RUSSELL, DC ;
DAVIES, SN .
BRAIN RESEARCH, 1995, 684 (02) :165-171