Gene therapy using HVJ-liposomes: the best of both worlds?

被引：88

作者：

Kaneda, Y ^{[1
]}

Saeki, Y ^{[1
]}

Morishita, R ^{[1
]}

机构：

[1] Osaka Univ, Sch Med, Div Gene Therapy Sci, Osaka 5650871, Japan

来源：

MOLECULAR MEDICINE TODAY | 1999年 / 5卷 / 07期

关键词：

D O I：

10.1016/S1357-4310(99)01482-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new concept for the development of novel vectors is to overcome the limitations of individual vectors by combining them. The HVJ-liposome was developed by combining liposomes with fusion proteins derived from the hemagglutinating virus of Japan (HVJ), also known as Sendai virus. Gene transfer in vivo using this delivery system can be repeated because it is much less immunogenic and cytotoxic than other viral-vector systems. By coupling the Epstein-Barr virus (EBV) replicon apparatus with HVJ-liposomes, transgene expression can be sustained in vitro and in vivo, In animal models, this system has shown promise for several diseases, including cancer and cardiovascular disease.

引用

页码：298 / 303

页数：6

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