Morin protects acute liver damage by carbon tetrachloride (CCl4) in rat

被引：55

作者：

Lee, Hee-Seung ^{[1
]}

Jung, Kyung-Hee ^{[1
]}

Hong, Sang-Won ^{[1
]}

Park, In-Suh ^{[1
]}

Lee, Chongmu ^{[2
]}

Han, Hyo-Kyung ^{[3
]}

Lee, Don-Haeng ^{[1
]}

Hong, Soon-Sun ^{[1
]}

机构：

[1] Inha Univ, Coll Med, Clin Res Ctr, Inchon 400712, South Korea

[2] Inha Univ, Dept Mat Sci & Engn, Inchon 402751, South Korea

[3] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 09期

关键词：

morin; antioxidant; carbon tetrachloride (CCl(4)); hepatic toxicity;

D O I：

10.1007/s12272-001-1283-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

The purpose of this study was to investigate possible beneficial effects of morin on CCl(4)-induced acute hepatotoxicity in rats. Rats received a single dose of CCl(4) (150 mu L/100 g 1:1 in corn oil). Morin treatment (20 mg/kg) was given at 48, 24, and 2 h before CCl4 administration. CCl(4) challenge elevated serum alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) levels, but these effects were prevented by the pretreatment of rats with morin. To identify the mechanism of protective activity of morin in CCl(4)-induced hepatotoxicity in rats, we investigated expressions of tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and inducible nitric oxide (iNOS). The expressions of TNF-alpha, IL-1 beta, IL-6, and iNOS were increased by CCl(4) treatment and increased expressions of those were decreased by morin. These findings suggest that morin prevents acute liver damage by inhibiting the production of TNF-alpha, IL-1 beta, IL-6, and iNOS.

引用

页码：1160 / 1165

页数：6

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