Lycaconitine revisited: Partial synthesis and neuronal nicotinic acetylcholine receptor affinities

被引：37

作者：

Jacyno, JM

Harwood, JS

Lin, NH

Campbell, JE

Sullivan, JP

Holladay, MW

机构：

[1] UNIV ILLINOIS, DEPT CHEM, CHICAGO, IL 60607 USA

[2] ABBOTT LABS, PHARMACEUT DISCOVERY, NEUROSCI RES, ABBOTT PK, IL 60064 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 07期

关键词：

D O I：

10.1021/np960352c

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The norditerpenoid alkaloid lycaconitine (2) was synthesized from lycoctonine (3) and its affinity determined for two neuronal nicotinic acetylcholine receptor subtypes. The structure of 2 was confirmed by a combination of spectroscopic methods.

引用

页码：707 / 709

页数：3

共 19 条

[1]

Arneric S. P., 1996, EXPERT OPIN INV DRUG, V5, P79, DOI [10.1517/13543784.5.1.79, DOI 10.1517/13543784.5.1.79]

[2]

ARNERIC SP, 1994, J PHARMACOL EXP THER, V270, P310

[3]

STRUCTURE DETERMINATION AND SPECTRAL ASSIGNMENT BY PULSED POLARIZATION TRANSFER VIA LONG-RANGE H-1-C-13 COUPLINGS [J].

BAX, A .

JOURNAL OF MAGNETIC RESONANCE, 1984, 57 (02) :314-318

[4]

Benn M.H., 1983, ALKALOIDS CHEM BIOL, V1, P153

[5]

ALKALOIDS OF DELPHINIUM BROWNII RYDB - STRUCTURE OF BROWNIINE [J].

BENN, MH ;

CAMERON, MAM ;

EDWARDS, OE .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1963, 41 (02) :477-&

[6]

THE FALL AND RISE OF NEURONAL ALPHA-BUNGAROTOXIN BINDING-PROTEINS [J].

CLARKE, PBS .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (11) :407-413

[7]

Jacyno J. M., 1996, CHEM TOXICOLOGY DIVE, P301

[8]

AN EFFICIENT SYNTHESIS OF QUINOLONES USING N-PHENYL(TRIPHENYLPHOSPHORANYLIDENE)ETHENIMINE [J].

KUMAR, P ;

DINESH, CU ;

PANDEY, B .

TETRAHEDRON LETTERS, 1994, 35 (49) :9229-9232

[9]

MARKS MJ, 1986, MOL PHARMACOL, V30, P427

[10]

PABREZA LA, 1991, MOL PHARMACOL, V39, P9

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