A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease

被引:79
作者
Best, O. G. [1 ]
Gardiner, A. C. [1 ]
Davis, Z. A. [1 ]
Tracy, I. [1 ]
Ibbotson, R. E. [1 ]
Majid, A. [2 ]
Dyer, M. J. S. [3 ]
Oscier, D. G. [1 ]
机构
[1] Royal Bournemouth Hosp, Dept Mol Biol & Cytogenet, Bournemouth, Dorset, England
[2] Univ Leicester, Toxicol Unit, MRC, Leicester, Leics, England
[3] Univ Hosp, Dept Haematol, Leicester, Leics, England
基金
英国医学研究理事会;
关键词
CHRONIC LYMPHOCYTIC-LEUKEMIA; MUTATIONAL STATUS;
D O I
10.1038/leu.2008.260
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:212 / 214
页数:3
相关论文
共 8 条
[1]   Emerging therapy for chronic lymphocytic leukaemia [J].
Auer, Rebecca L. ;
Gribben, John ;
Cotter, Finbarr E. .
BRITISH JOURNAL OF HAEMATOLOGY, 2007, 139 (05) :635-644
[2]   A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL [J].
Best, O. G. ;
Gardiner, A. C. ;
Majid, A. ;
Walewska, R. ;
Austen, B. ;
Skowronska, A. ;
Ibbotson, R. ;
Stankovic, T. ;
Dyer, M. J. S. ;
Oscier, D. G. .
LEUKEMIA, 2008, 22 (07) :1456-1459
[3]   Assessment of fludarabine plus cyclophosphamide for patients with chronic lymphocytic leukaemia (the LRF CLL4 Trial): a randomised controlled trial [J].
Catovsky, D. ;
Richards, S. ;
Matutes, E. ;
Oscier, D. ;
Dyer, M. J. S. ;
FBezares, R. ;
Pettitt, A. R. ;
Hamblin, T. ;
Milligan, D. W. ;
Child, J. A. ;
Hamilton, M. S. ;
Dearden, C. E. ;
Smith, A. G. ;
Bosanquet, A. G. ;
Davis, Z. ;
Brito-Babapulle, V. ;
Else, M. ;
Wade, R. ;
Hillmen, P. .
LANCET, 2007, 370 (9583) :230-239
[4]  
DORHNER H, 2000, NEW ENGL J MED, V343, P1910
[5]   Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status [J].
Mockridge, C. Ian ;
Potter, Kathleen N. ;
Wheatley, Isla ;
Neville, Louise A. ;
Packham, Graham ;
Stevenson, Freda K. .
BLOOD, 2007, 109 (10) :4424-4431
[6]   Multivariate analysis of prognostic factors in CLL:: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors [J].
Oscier, DG ;
Gardiner, AC ;
Mould, SJ ;
Glide, S ;
Davis, ZA ;
Ibbotson, RE ;
Corcoran, MM ;
Chapman, RM ;
Thomas, PW ;
Copplestone, JA ;
Orchard, JA ;
Hamblin, TJ .
BLOOD, 2002, 100 (04) :1177-1184
[7]   Alemtuzumab in combination with high-dose methylprednisolone is a logical, feasible and highly active therapeutic regimen in chronic lymphocytic leukaemia patients with p53 defects [J].
Pettitt, A. R. ;
Matutes, E. ;
Oscier, D. .
LEUKEMIA, 2006, 20 (08) :1441-1445
[8]  
Zenz T, 2007, BLOOD, V110, p615A