Ferric ion could facilitate osteoclast differentiation and bone resorption through the production of reactive oxygen species

被引：243

作者：

Jia, Peng ^{[1
]}

Xu, You Jia ^{[1
]}

Zhang, Zeng Li ^{[2
]}

Li, Kai ^{[3
]}

Li, Bingyan ^{[2
]}

Zhang, Wen ^{[4
]}

Yang, Huilin ^{[5
]}

机构：

[1] Soochow Univ, Affiliated Hosp 2, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Med, Sch Publ Hlth, Suzhou, Jiangsu, Peoples R China

[3] Soochow Univ, Dept Pharmaceut Sci, Suzhou, Jiangsu, Peoples R China

[4] Soochow Univ, Orthopaed Res Inst, Suzhou, Jiangsu, Peoples R China

[5] Soochow Univ, Affiliated Hosp 1, Dept Orthopaed, Suzhou, Jiangsu, Peoples R China

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 2012年 / 30卷 / 11期

关键词：

iron; osteoclast; reactive oxygen species; POSTMENOPAUSAL OSTEOPOROSIS; OXIDATIVE STRESS; IRON OVERLOAD; MINERAL DENSITY; HEALTH; MODEL; RISK; CELL;

D O I：

10.1002/jor.22133

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Iron overload is widely regarded as a risk factor for osteoporosis. It has been demonstrated that iron can inhibit osteoblast differentiation. However, the effects of iron on osteoclast differentiation and bone resorption remain controversial. In this study, we found that ferric ion promoted Receptor Activator of Nuclear Factor ? B Ligand (RANKL)-induced osteoclast (OC) formation in both RAW264.7 cells and bone marrow-derived macrophages (BMMs), and this effect was accompanied by elevated levels of reactive oxygen species (ROS) and oxidative stress. Moreover, this effect was attenuated by the administration of antioxidant N-acetyl-L-cysteine (NAC). Therefore, we conclude that ferric ion can promote osteoclast differentiation and bone resorption through the production of ROS. (c) 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 30:18431852, 2012

引用

页码：1843 / 1852

页数：10

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