Depression and Hippocampal Neurogenesis: A Road to Remission?

被引：453

作者：

Eisch, Amelia J. ^{[1
]}

Petrik, David ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA

来源：

SCIENCE | 2012年 / 338卷 / 6103期

关键词：

ANTIDEPRESSANT TREATMENT; ADULT NEUROGENESIS; CELL-PROLIFERATION; PATTERN SEPARATION; STRESS RESPONSES; GRANULE CELLS; ANIMAL-MODEL; BEHAVIOR; BRAIN; QUESTIONS;

D O I：

10.1126/science.1222941

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Adult-generated hippocampal neurons are required for mood control and antidepressant efficacy, raising hopes that someday we can harness the power of new neurons to treat mood disorders such as depression. However, conflicting findings from preclinical research-involving stress, depression, and neurogenesis-highlight the complexity of considering neurogenesis as a road to remission from depression. To reconcile differences in the literature, we introduce the "neurogenic interactome," a platform from which to consider the diverse and dynamic factors regulating neurogenesis. We propose consideration of the varying perspectives-system, region, and local regulation of neurogenesis-offered by the interactome and exchange of ideas between the fields of learning and memory and mood disorder research to clarify the role of neurogenesis in the etiology and treatment of depression.

引用

页码：72 / 75

页数：4

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