Combinatorial bio/chemical analysis of dioxin and dioxin-like compounds in waste recycling, feed/food, humans/wildlife and the environment

被引:93
作者
Behnisch, PA [1 ]
Hosoe, K [1 ]
Sakai, S [1 ]
机构
[1] Kaneka Corp, Life Sci Res Labs, Takasago, Hyogo, Japan
关键词
bioassay; biomarker; biomonitoring; waste recycling; dioxins; dioxin-like compounds; dioxin toxicity equivalent quotient (TEQ); relative responses (REPs);
D O I
10.1016/S0160-4120(01)00029-0
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The present review describes international activities using bioassays/biomarkers in combination with chemical analysis to measure the effects of dioxin and dioxin-like compounds (DLCs) in the environment. The above authors reviewed already the state-of-art bioanalytical detection methods (BDMs) for dioxins and DLCs [Environ Int (2001)]. The aim of this study will be to review applications of these bioassays/biomarkers to evaluate potential dioxins and DLCs. The present literature study lists relative potencies (REPs) of polyhalogenated dibenzo-p-dioxins and -furans (PXDD/Fs; X = Cl, Br, F), their thio analogues polychlorinated dibenzothiophenes (PCDTs) and thianthrens (PCTAs), polyhalogenated biphenyls (PXBs), polychlorinated naphthalenes (PCNs) and other Ah receptor agonists measured by several biodetectors (Tier 3 screening). The authors will discuss some examples of the applications of some of these biodetectors in biomonitoring programmes and recently occurred dioxin crisis in feed/food. The diagnosis of the biopotency of these pollutants in technical processes like thermally treated waste, waste water treatment, landfill leachate treatment, commercial PCB-mixtures, the release into the environment (soil, air and water) and the final intake into wildlife and humans will be reviewed. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:495 / 519
页数:25
相关论文
共 256 条
  • [1] AARTS JMM, 1996, ORGANOHALOGEN COMPOU, V27, P285
  • [2] ABRAHAM K, 1999, ORGANOHALOGEN COMPD, V44, P47
  • [3] TOXIC EQUIVALENCY FACTORS FOR DIOXIN-LIKE PCBS - REPORT ON A WHO-ECEH AND IPCS CONSULTATION, DECEMBER 1993
    AHLBORG, UG
    BECKING, GC
    BIRNBAUM, LS
    BROUWER, A
    DERKS, HJGM
    FEELEY, M
    GOLOR, G
    HANBERG, A
    LARSEN, JC
    LIEM, AKD
    SAFE, SH
    SCHLATTER, C
    WAERN, F
    YOUNES, M
    YRJANHEIKKI, E
    [J]. CHEMOSPHERE, 1994, 28 (06) : 1049 - 1067
  • [4] Dioxin-like PCBs in the environment - Human exposure and the significance of sources
    Alcock, RE
    Behnisch, PA
    Jones, KC
    Hagenmaier, H
    [J]. CHEMOSPHERE, 1998, 37 (08) : 1457 - 1472
  • [5] Correlation of CYP1A1 induction, as measured by the P450 RGS biomarker assay, with high molecular weight PAHs in mussels deployed at various sites in San Diego Bay in 1993 and 1995
    Anderson, JW
    Jones, JM
    Steinert, S
    Sanders, B
    Means, J
    McMillin, D
    Vu, T
    Tukey, R
    [J]. MARINE ENVIRONMENTAL RESEARCH, 1999, 48 (4-5) : 389 - 405
  • [6] Correlation between response of human cell line and distribution of sediment polycyclic aromatic hydrocarbons and polychlorinated biphenyls on Palos Verdes Shelf California, USA
    Anderson, JW
    Zeng, EY
    Jones, JM
    [J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1999, 18 (07) : 1506 - 1510
  • [7] Comparative analysis of sediment extracts from NOAA's bioeffects studies by the biomarker, P450 Reporter Gene System
    Anderson, JW
    Jones, JM
    Hameedi, J
    Long, E
    Tukey, RH
    [J]. MARINE ENVIRONMENTAL RESEARCH, 1999, 48 (4-5) : 407 - 425
  • [8] ANDERSON JW, 2000, ORGANOHALOGEN COMPD, V45, P208
  • [9] When you cut down a tree, keep an eye on the forest
    Anderson, SE
    Ness, AI
    [J]. PROCESS SAFETY PROGRESS, 2000, 19 (01) : 5 - 8
  • [10] BIOASSAY-DERIVED 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN EQUIVALENTS IN PCB-CONTAINING EXTRACTS FROM THE FLESH AND EGGS OF LAKE-MICHIGAN CHINOOK SALMON (ONCORHYNCHUS-TSHAWYTSCHA) AND POSSIBLE IMPLICATIONS FOR REPRODUCTION
    ANKLEY, GT
    TILLITT, DE
    GIESY, JP
    JONES, PD
    VERBRUGGE, DA
    [J]. CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES, 1991, 48 (09) : 1685 - 1690