Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp.

被引：31

作者：

Andersen, YS

Gillin, FD

Eckmann, L

机构：

[1] Univ Calif San Diego, Dept Med 0665, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Pathol, Div Infect Dis, La Jolla, CA 92093 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 04期

关键词：

D O I：

10.1128/IAI.74.4.2473-2476.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Humans infected with Giardia exhibit intestinal hypermotility, but the underlying mechanisms and functional significance are uncertain. Here we show in murine models of giardiasis that small-intestinal hypermotility occurs in a delayed fashion relative to peak parasite burden, is dependent on adaptive immune defenses, and contributes to giardial clearance.

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页码：2473 / 2476

页数：4

相关论文

共 23 条

[1] Traveller's diarrhoea [J].

Al-Abri, SS ;

Beeching, NJ ;

Nye, FJ .

LANCET INFECTIOUS DISEASES, 2005, 5 (06) :349-360

[2] LOPERAMIDE - SURVEY OF STUDIES ON MECHANISM OF ITS ANTIDIARRHEAL ACTIVITY [J].

AWOUTERS, F ;

MEGENS, A ;

VERLINDEN, M ;

SCHUURKES, J ;

NIEMEGEERS, C ;

JANSSEN, PAJ .

DIGESTIVE DISEASES AND SCIENCES, 1993, 38 (06) :977-995

[3] GIARDIA-LAMBLIA INFECTIONS IN ADULT MICE [J].

BYRD, LG ;

CONRAD, JT ;

NASH, TE .

INFECTION AND IMMUNITY, 1994, 62 (08) :3583-3585

[4]

CASTRO GA, 1976, GASTROENTEROLOGY, V71, P620

[5] Effects of Giardia lamblia infection on gastrointestinal transit and contractility in Mongolian gerbils [J].

Deselliers, LP ;

Tan, DTM ;

Scott, RB ;

Olson, ME .

DIGESTIVE DISEASES AND SCIENCES, 1997, 42 (12) :2411-2419

[6] Mucosal defences against Giardia [J].

Eckmann, L .

PARASITE IMMUNOLOGY, 2003, 25 (05) :259-270

[7] PROPULSIVE ACTIVITY OF THE RAT SMALL-INTESTINE DURING INFECTION WITH THE NEMATODE NIPPOSTRONGYLUS-BRASILIENSIS [J].

FARMER, SG .

PARASITE IMMUNOLOGY, 1981, 3 (03) :227-234

[8] Immune response to Giardia duodenalis [J].

Faubert, G .

CLINICAL MICROBIOLOGY REVIEWS, 2000, 13 (01) :35-+

[9] Central importance of immunoglobulin a in host defense against Giardia spp. [J].

Langford, TD ;

Housley, MP ;

Boes, M ;

Chen, JZ ;

Kagnoff, MF ;

Gillin, FD ;

Eckmann, L .

INFECTION AND IMMUNITY, 2002, 70 (01) :11-18

[10] Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice [J].

Li, EQ ;

Zhou, P ;

Singer, SM .

JOURNAL OF IMMUNOLOGY, 2006, 176 (01) :516-521