Assessment of ovarian reserve following ovarian tissue banking and/or GnRH-a co-treatment prior to chemotherapy in patients with Hodgkin's disease

被引：19

作者：

Azem, Foad ^{[1
]}

Samara, Nivin ^{[1
]}

Cohen, Tanya ^{[1
]}

Ben-Yosef, Dalit ^{[1
]}

Almog, Beni ^{[1
]}

Lessing, Joseph B. ^{[1
]}

Goor, Odeliya ^{[1
]}

Amit, Ami ^{[1
]}

机构：

[1] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Racine IVF Unit, Lis Matern Hosp,Sackler Fac Med, IL-64239 Tel Aviv, Israel

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2008年 / 25卷 / 11-12期

关键词：

Hodgkin's disease; Chemotherapy; Ovarian tissue cryopreservation; GnRH-a; Ovarian reserve;

D O I：

10.1007/s10815-008-9276-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To examine ovarian reserve following chemotherapy in women with Hodgkin's disease. The study included nine patients who underwent ovarian tissue cryopreservation (OTCP) prior to chemotherapy consisting of the ABVD regimen (Adriamycin, bleomycin, vinblastine, and dacarbazine) and co-treatment with gonadotropin-releasing hormone agonist (GnRH-a) (Group A), and 13 patients treated by the ABVD protocol only without GnRH-a (Group B). The average age was 25.2 +/- 2.7 years for the women in Group A and 31.8 +/- 6.8 years for those in Group B. Six months following the end of chemotherapy, the menstrual cycle resumed in all Group A patients and in four Group B patients who had amenorrhea. Eight Group B patients had regular menses during and after chemotherapy. None of the patients suffered from ovarian failure. Two Group A patients conceived in the first year after completing chemotherapy. Co-treatment with GnRH-a has little effect on ovarian protection in women with Hodgkin's disease.

引用

页码：535 / 538

页数：4

共 17 条

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