Tissue engineering: chondrocytes and cartilage

被引：102

作者：

Hardingham, Tim ^{[1
]}

Tew, Simon ^{[1
]}

Murdoch, Alan ^{[1
]}

机构：

[1] Univ Manchester, Sch Biol Sci, UK Ctr Tissue Engn, Manchester, Lancs, England

来源：

ARTHRITIS RESEARCH & THERAPY | 2002年 / 4卷 / Suppl 3期

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

extracellular matrix; joint disease; osteoarthritis; regenerative medicine;

D O I：

10.1186/ar561

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Tissue engineering offers new strategies for developing treatments for the repair and regeneration of damaged and diseased tissues. These treatments, using living cells, will exploit new developments in understanding the principles in cell biology that control and direct cell function. Arthritic diseases that affect so many people and have a major impact on the quality of life provide an important target for tissue engineering. Initial approaches are in cartilage repair; in our own programme we are elucidating the signals required by chondrocytes to promote new matrix assembly. These principles will extend to other tissues of the musculoskeletal system, including the repair of bone, ligament and tendon.

引用

页码：S63 / S68

页数：6

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