Processing body autoantibodies reconsidered

被引：6

作者：

Bloch, DB

Gulick, T

Bloch, KD

Yang, WH

机构：

[1] Massachusetts Gen Hosp, Dept Med, Charlestown, MA 02129 USA

[2] Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Charlestown, MA 02114 USA

[3] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Med, Charlestown, MA 02114 USA

[5] Massachusetts Gen Hosp, Diabet Res Lab, Charlestown, MA 02114 USA

[6] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA 02114 USA

[7] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

RNA | 2006年 / 12卷 / 05期

关键词：

mRNA processing body; mRNA decay; RISC complex; autoantigen;

D O I：

10.1261/ rna.17406

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Processing bodies (P-bodies) are cellular structures that have critical roles in mRNA degradation and post-transcriptional gene silencing. Some patients with autoimmune disease have high titer antibodies directed against P-bodies, and certain sera have been used as markers for the GW182 component of these structures. This study shows that available reference sera are unreliable markers for GW182 because the sera contain antibodies directed against Ge-1, a second P-body autoantigen.

引用

收藏

页码：707 / 709

页数：3

相关论文

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