Changes in mitochondrial DNA copy number in blood cells from HIV-infected patients undergoing antiretroviral therapy

被引：34

作者：

de Mendoza, C

de Ronde, A

Smolders, K

Blanco, F

Garcia-Benayas, T

de Baar, M

Fernández-Casas, P

González-Lahoz, J

Soriano, V

机构：

[1] Hosp Carlos III, Infect Dis Serv, Madrid, Spain

[2] Primagen, Amsterdam, Netherlands

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2004年 / 20卷 / 03期

关键词：

D O I：

10.1089/088922204322996491

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Mitochondrial DNA (mtDNA) copy number was measured in peripheral blood mononuclear cells (PBMCs) from 69 individuals using a real-time NASBA quantitative assay. Patients with HIV infection harbored significantly lower mtDNA copy number in PBMC than HIV-negative controls. Besides, subjects on stavudine-containing regimens showed significantly lower median mtDNA amounts than HIV-positive patients receiving other antiretroviral drugs, and this was associated with higher lactate levels. Thus, either HIV infection itself or treatment with stavudine-containing regimens might induce mtDNA depletion and related metabolic disturbances as hyperlactatemia.

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页码：271 / 273

页数：3

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