Microwave assisted synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene skeletons as inhibitors of the carbonic anhydrases isoforms I, II, IV and VII

被引：15

作者：

Esirden, Ibrahim ^{[1
]}

Tanc, Muhammet ^{[2
]}

Supuran, Claudiu T. ^{[2
]}

Kaya, Muharrem ^{[3
]}

机构：

[1] Dumlupinar Univ, Fac Arts & Sci, Dept Chem, TR-43100 Kutahya, Turkey

[2] Univ Florence, NEUROFARBA Dept, Sez Sci Farmaceut & Nutraceut, I-50019 Florence, Italy

[3] Dumlupinar Univ, Fac Arts & Sci, Dept Biochem, TR-43100 Kutahya, Turkey

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2017年 / 27卷 / 01期

关键词：

Tetrazole; Sulfonamide; Octahydroacridine; Chromene; Carbonic anhydrase; Enzyme inhibition; ACRIDINE-DERIVATIVES; HIGHLY EFFICIENT; SULFONAMIDE DERIVATIVES; ANTIMICROBIAL ACTIVITY; AGENTS; ACTIVATORS; FACILE;

D O I：

10.1016/j.bmcl.2016.11.028

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The synthesis of novel tetrazole/sulfonamide derivatives based on octahydroacridine, xanthene and chromene scaffold by using microwave (MW) assisted techniques is reported in this study. These synthesized hybrid compounds were assayed for the inhibition of carbonic anhydrase (CA, EC 4.2.1.1). The inhibitory activities were determined against three cytosolic human isoforms (hCA I, II and VII) and one membraneassociated (hCA IV) isoform. Some of the newly synthesized sulfonamides showed micromolar to nanomolar inhibitory activity against these enzymes. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：86 / 89

页数：4

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