Endogenous heparin activity deficiency: the 'Missing Link' in atherogenesis?

被引：17

作者：

Engelberg, H ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Los Angeles, CA 90210 USA

来源：

ATHEROSCLEROSIS | 2001年 / 159卷 / 02期

关键词：

atherogenesis; endogenous heparin deficiency;

D O I：

10.1016/S0021-9150(01)00650-5

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

This paper reviews published studies since 1995 dealing with many atherogenic mechanisms where exogenous heparin was beneficial. In these areas endogenous heparin deficiency is likely to be harmful. Mechanisms included inflammatory factors, lower endogenous plasma heparin levels, lipoprotein lipase, chemokines, APOE e4, lipoprotein(a), among others. Demonstrated reduction of heparan sulfate proteoglycans (HSPG) and of endogenous plasma heparin was reviewed. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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页码：253 / 260

页数：8

相关论文

共 97 条

[1]

Chemokines: Leucocyte recruitment and activation cytokines [J].

Adams, DH ;

Lloyd, AR .

LANCET, 1997, 349 (9050) :490-495

[2]

Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-α [J].

Ahmad, M ;

Theofanidis, P ;

Medford, RM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (08) :4616-4621

[3]

ALTAMASIO M, 1998, THROMB HEMOST, V79, P959

[4]

AUVERS JH, 1989, EUR J CLIN INVEST, V1, P433

[5]

Human chemokines: An update [J].

Baggiolini, M ;

Dewald, B ;

Moser, B .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :675-705

[6]

NONENZYMATIC GLYCATION OF FIBROUS COLLAGEN - REACTION-PRODUCTS OF GLUCOSE AND RIBOSE [J].

BAILEY, AJ ;

SIMS, TJ ;

AVERY, NC ;

HALLIGAN, EP .

BIOCHEMICAL JOURNAL, 1995, 305 :385-390

[7]

Mechanisms of disease - Nuclear factor-kappa b - A pivotal transcription factor in chronic inflammatory diseases [J].

Barnes, PJ ;

Larin, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (15) :1066-1071

[8]

Batalla A, 1999, J AM COLL CARDIOL, V33, P590

[9]

RECENT ADVANCES IN MOLECULAR PATHOLOGY - CARBOHYDRATE PROTEIN MACROMOLECULES AND ARTERIAL-WALL INTEGRITY - A ROLE IN ATHEROGENESIS [J].

BERENSON, GS ;

RADHAKRISHNAMURTHY, B ;

SRINIVASAN, SR ;

VIJAYAGOPAL, P ;

DALFERES, ER ;

SHARMA, C .

EXPERIMENTAL AND MOLECULAR PATHOLOGY, 1984, 41 (02) :267-287

[10]

Prolonged postprandial responses of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein epsilon 4 allele [J].

Bergeron, N ;

Havel, RJ .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (01) :65-72

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