Human umbilical cord Wharton's jelly stem cells: Immune property genes assay and effect of transplantation on the immune cells of heart failure patients

被引：20

作者：

Chen, Haiying ^{[1
,2
]}

Zhang, Ningkun ^{[1
]}

Li, Tianchang ^{[1
]}

Guo, Jianwei ^{[3
]}

Wang, Zhiguo ^{[1
]}

Yang, Ming ^{[3
]}

Gao, Lianru ^{[1
]}

机构：

[1] Navy Gen Hosp, Ctr Cardiol, Beijing 100048, Peoples R China

[2] 210th Hosp PLA, Dept Endocrinol, Dalian 116021, Liaoning, Peoples R China

[3] Navy Gen Hosp, Dept Lab Med, Beijing 100048, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2012年 / 276卷 / 1-2期

关键词：

Wharton's jelly; Stem cells; Immunomodulation; Immunity; Cell transplantation; MESENCHYMAL STROMAL CELLS; INHIBIT LYMPHOCYTE-PROLIFERATION; HLA-G; BONE-MARROW; RAT; DIFFERENTIATION; SUPPRESSION; ACTIVATION; EXPRESSION; THERAPY;

D O I：

10.1016/j.cellimm.2012.03.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stem cells derived from umbilical cord Wharton's jelly (WJSCs) are not immunogenic and have immunosuppressive effects. To evaluate the related mechanisms and the effect of transplantation on body immune cells, we examined immune property genes expression in WJSCs and levels of T-lymphocytes subgroups and immunoglobulins (Ig) in heart failure (HF) patients with and without WJSCs transplantation. WJSCs express immune tolerance genes HLA-E, HLA-G and HLA-F and immunomodulation genes VEGF, TGE beta 1, HGF, HMOX1, IL1 beta, IL-6, LIF, LGALS-1/3/8, COX1/2 and PTGE, while they do not express immune response-related genes HLA-DR, HLA-DQ, HLA-DP, CD80, CD86, CD40 and CD40L. No obvious changes of T-lymphocytes subgroups and plasma IgG/IgM were observed in HF patients with WJSCs transplantation. Our results suggest that the immune properties of WJScs are due to the expression of immune avoidance and immunomodulation genes in the absence of immune response-related genes. WJSCs are secure in immunological aspects when used as seed cells for cardiac repair. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：83 / 90

页数：8

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