Hoxa3 regulates integration of glossopharyngeal nerve precursor cells

被引:26
作者
Watari, N
Kameda, Y
Takeichi, M
Chisaka, O [1 ]
机构
[1] Kyoto Univ, Grad Sch Biostudies, Dept Cell & Dev Biol, Sakyo Ku, Kyoto 6068502, Japan
[2] Kitasato Univ, Sch Med, Dept Anat, Sagamihara, Kanagawa 2288555, Japan
基金
日本学术振兴会;
关键词
Hoxa3; glossopharyngeal nerve; neural crest; placode; axon guidance; hindbrain; cell migration;
D O I
10.1006/dbio.2001.0447
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In vertebrates, certain Hox genes are known to control cellular identities along the anterior-posterior (A-P) axis in the developing hindbrain. In mouse Hoxa3 mutants, truncation of the glossopharyngeal (IXth) nerve or the fusion of the Ixth and vagus (Xth) nerves was reported, although its underlying mechanism is largely unknown. To elucidate the mechanism of the IXth nerve defects, we reexamined the phenotype of Hoxa3 mutant embryos. In Hoxa3 mutants, we observed an abnormal caudal stream of the migrating Hoxa3-expressing neural crest cells at the prospective IXth nerve-forming area. Dorsomedial migration of the placode-derived neuronal precursor cells of the IXth nerve was also affected. Motor neurons at rhombomere 6 (r6), where those of the IXth nerve were positioned, often projected axons to the Xth nerve. In summary, the Hoxa3 gene has crucial roles in ensuring the correct axon projection pattern of all three components of the IXth nerve, i.e., motor neurons and sensory neurons of the proximal and distal ganglia. (C) 2001 Academic Press.
引用
收藏
页码:15 / 31
页数:17
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