A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls:: A double-blinded randomized placebo-controlled 1-year intervention

被引：128

作者：

Viljakainen, Heli T.

Natri, Anna-Mari

Karkkainen, Merja

Huttunen, Minna M.

Palssa, Anette

Jakobsen, Jette

Cashman, Kevin D.

Molgaard, Christian

Lamberg-Allardt, Christel

机构：

[1] Univ Helsinki, Dept Appl Chem & Microbiol, Calcium Res Unit, FIN-00014 Helsinki, Finland

[2] Danish Inst Food & Vet Res, Soborg, Denmark

[3] Dept Food & Nutr Sci, Cork, Ireland

[4] Royal Vet & Agr Univ, Dept Human Nutr, Ctr Adv Food Studies, Frederiksberg C, Denmark

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2006年 / 21卷 / 06期

关键词：

vitamin D-3 supplementation; adequate calcium intake; adolescent girls; bone mineral augmentation;

D O I：

10.1359/JBMR.060302

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner. Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.

引用

收藏

页码：836 / 844

页数：9

相关论文

共 45 条

[1] TO WHAT EXTENT IS BONE MASS DETERMINED BY FAT-FREE OR FAT MASS [J].

ALOIA, JF ;

VASWANI, A ;

MA, RM ;

FLASTER, E .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1995, 61 (05) :1110-1114

[2] Teenage girls and elderly women living in northern Europe have low winter vitamin D status [J].

Andersen, R ;

Molgaard, C ;

Skovgaard, LT ;

Brot, C ;

Cashman, KD ;

Chabros, E ;

Charzewska, J ;

Flynn, A ;

Jakobsen, J ;

Kärkkäinen, M ;

Kiely, M ;

Lamberg-Allardt, C ;

Moreiras, O ;

Natri, AM ;

O'Brien, M ;

Rogalska-Niedzwiedz, M ;

Ovesen, L .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2005, 59 (04) :533-541

[3] Vitamin D2 is much less effective than vitamin D3 in humans [J].

Armas, LAG ;

Hollis, BW ;

Heaney, RP .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (11) :5387-5391

[4] EPIDEMIOLOGY OF FRACTURES OF THE DISTAL END OF THE RADIUS IN CHILDREN AS ASSOCIATED WITH GROWTH [J].

BAILEY, DA ;

WEDGE, JH ;

MCCULLOCH, RG ;

MARTIN, AD ;

BERNHARDSON, SC .

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 1989, 71A (08) :1225-1231

[5] The differing tempo of growth in bone size, mass, and density in girls is region-specific [J].

Bass, S ;

Delmas, PD ;

Pearce, G ;

Hendrich, E ;

Tabensky, A ;

Seeman, E .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (06) :795-804

[6] Calcium-enriched foods and bone mass growth in prepubertal girls: A randomized, double-blind, placebo-controlled trial [J].

Bonjour, JP ;

Carrie, AL ;

Ferrari, S ;

Clavien, H ;

Slosman, D ;

Theintz, G ;

Rizzoli, R .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 99 (06) :1287-1294

[7]

BONJOUR JP, 1994, OSTEOPOROSIS INT, V4, P7

[8] The effect of calcium supplementation on bone density in premenarcheal females: A co-twin approach [J].

Cameron, MA ;

Paton, LM ;

Nowson, CA ;

Margerison, C ;

Frame, M ;

Wark, JD .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (10) :4916-4922

[9] Self-reported calcium intake and bone mineral content in children and adolescents [J].

Carter, LM ;

Whiting, SJ ;

Drinkwater, DT ;

Zello, GA ;

Faulkner, RA ;

Bailey, DA .

JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2001, 20 (05) :502-509

[10] No effect of copper supplementation on biochemical markers of bone metabolism in healthy young adult females despite apparently improved copper status [J].

Cashman, KD ;

Baker, A ;

Ginty, F ;

Flynn, A ;

Strain, JJ ;

Bonham, MP ;

O'Connor, JM ;

Bügel, S ;

Sandström, B .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2001, 55 (07) :525-531

← 1 2 3 4 5 →