New synthetic heparin mimetics able to inhibit thrombin and factor Xa

被引：33

作者：

Petitou, M ^{[1
]}

Duchaussoy, P ^{[1
]}

Driguez, PA ^{[1
]}

Hérault, JP ^{[1
]}

Lormeau, JC ^{[1
]}

Herbert, JM ^{[1
]}

机构：

[1] Sanofi Rech, Haemobiol Res Dept, F-31036 Toulouse, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00155-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic pentadeca-, heptadeca- and nonadecasaccharides, comprising an antithrombin III (AT III) binding pentasaccharide prolonged at the non-reducing end by a thrombin binding domain have been obtained. The pentadecasaccharide is the shortest oligosaccharide able to catalyse thrombin inhibition by AT III. The nonadecasaccharide is a more potent thrombin inhibitor than standard heparin. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1155 / 1160

页数：6

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