Changes of Peroxisome Proliferator-Activated Receptor-γ on Crushed Rat Sciatic Nerves and Differentiated Primary Schwann Cells

被引：20

作者：

Cao, Yi ^{[2
]}

Wang, Qiuhong ^{[3
]}

Zhou, Zhengming ^{[2
]}

Wang, Youhua ^{[2
]}

Liu, Yonghua ^{[3
]}

Ji, Yuhong ^{[3
]}

Liu, Fan ^{[1
]}

机构：

[1] Nantong Univ, Dept Orthopaed, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China

[2] Soochow Univ, Dept Orthopaed, Affiliated Hosp 1, Coll Med, Suzhou 215123, Jiangsu, Peoples R China

[3] Nantong Univ, Dept Immunol, Coll Med, Nantong 226001, Peoples R China

来源：

JOURNAL OF MOLECULAR NEUROSCIENCE | 2012年 / 47卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Schwann cells; Differentiation; PPAR-gamma; c-AMP; 15-Deoxy-Delta(12,14)-prostaglandin J(2); Rosiglitazone; LUNG-CARCINOMA CELLS; PPAR-GAMMA; PERIPHERAL-NERVE; GENE-EXPRESSION; PROTEIN-KINASE; UP-REGULATION; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); TISSUE DISTRIBUTION; SKELETAL-MUSCLE; FATTY-ACIDS;

D O I：

10.1007/s12031-011-9662-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been found to play an essential role in cell proliferation, but whether it was involved in Schwann cells differentiation has never been studied. We have found in sciatic nerve injury that expression of PPAR-gamma decreases mainly in Schwann cells, and it was also increased in differentiated Schwann cells. Further, activated PPAR-gamma by the endogenous ligand 15 d-PGJ(2) increased expressions of PPAR-gamma level and Schwann cell differentiation, and this effect may be protected by its antagonist GDW9662. These results indicate that PPAR-gamma could promote Schwann cell differentiation, which plays an important role in peripheral nerve injury and regeneration.

引用

页码：380 / 388

页数：9

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