Hippocampal pyramidal cell-interneuron spike transmission is frequency dependent and responsible for place modulation of interneuron discharge

被引：88

作者：

Marshall, L ^{[1
]}

Henze, DA ^{[1
]}

Hirase, H ^{[1
]}

Leinekugel, X ^{[1
]}

Dragoi, G ^{[1
]}

Buzsáki, G ^{[1
]}

机构：

[1] Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA

来源：

JOURNAL OF NEUROSCIENCE | 2002年 / 22卷 / 02期

关键词：

hippocampus; spike transmission; interneuron; depression; place cells; temporal coding;

D O I：

10.1523/JNEUROSCI.22-02-j0001.2002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The inter-play between principal cells and interneurons plays an important role in timing the activity of individual cells. We investigated the influence of single hippocampal CA1 pyramidal cells on putative interneurons. The activity of CA1 pyramidal cells was controlled intracellularly by current injection, and the activity of neighboring interneurons was recorded extracellularly in the urethane-anesthetized rat. Spike transmission probability between monosynaptic ally connected pyramidal cell-interneuron pairs was frequency dependent and highest between 5 and 25 Hz. In the awake animal, interneurons were found that had place-modulated firing rates, with place maps similar to their presynaptic pyramidal neuron. Thus, single pyramidal neurons can effectively determine the firing patterns of their interneuron targets.

引用

页数：10

共 40 条

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