Migration and function of a glial subtype in the vertebrate peripheral nervous system

被引：229

作者：

Gilmour, DT ^{[1
]}

Maischein, HM ^{[1
]}

Nüsslein-Volhard, C ^{[1
]}

机构：

[1] Max Planck Inst Entwicklungsbiol, Genet Abt, D-72076 Tubingen, Germany

来源：

NEURON | 2002年 / 34卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0896-6273(02)00683-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glia-axon interactions are essential for the development and function of the nervous system. We combine in vivo imaging and genetics to address the mechanism by which the migration of these cells is coordinated during embryonic development. Using stable transgenic lines, we have followed the migration of one subset of glial cells and their target axons in living zebrafish embryos. These cells coalesce at an early stage and remain coupled throughout migration, with axons apparently pathfinding for glia. Mutant analysis demonstrates that axons provide instructive cues that are sufficient to control glial guidance. Furthermore, mutations in the transcription factor Sox10/cls uncouple the migration of axons and glia. Finally, genetic ablation of this glial subtype reveals an essential role in nerve fasciculation.

引用

页码：577 / 588

页数：12

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