An additional 2′-ribofuranose residue at a specific position of the DNA primer prevents its elongation by HIV-1 reverse transcriptase

被引：12

作者：

Andreeva, OI

Golubeva, AS

Kochetkov, SN

Van Aerschot, A

Herdewijn, P

Efimtseva, EV

Ermolinsky, BS

Mikhailov, SN

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Katholieke Univ Leuven, Rega Inst, B-3000 Louvain, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

D O I：

10.1016/S0960-894X(01)00836-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Oligodeoxynucleotides containing 2'-O-beta-D-ribofuranosyladenosine were prepared and used as modified primers in RNA-templated DNA synthesis catalyzed by HIV reverse transcriptase. It was shown that the additional 2'-ribofuranose residue in specific position of primer prevents its elongation. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：681 / 684

页数：4

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