Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells

被引:78
作者
Shaw, M [1 ]
Cohen, P [1 ]
机构
[1] Univ Dundee, Dept Biochem, MRC, Prot Phosphorylat Unit, Dundee DD1 5EH, Scotland
基金
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
protein kinase B; epidermal growth factor; insulin; MAP kinase; glycogen synthase kinase 3;
D O I
10.1016/S0014-5793(99)01434-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epidermal growth factor (EGF), insulin-like growth factor 1 (IGF1) and phorbol myristate acetate (PMA) induce the inhibition of glycogen synthase kinase 3 (GSK3) by stimulating the phosphorylation of an N-terminal serine, Here, we show that protein kinase B (PKB) plays a kev role in mediating EGF-induced inhibition of GSK3 alpha and that the classical MAP kinase (MAPK) cascade has two functions in this process. Firstly, it makes a transient contribution to EGF-induced inhibition of GSK3 alpha. Secondly, it shortens the duration of PKB activation and GSK3 alpha inhibition. In contrast, PKB alone mediates the IGF1-induced inhibition of GSK3 alpha, while the MAPK cascade mediates the inhibition of GSK3a by PMA. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码:120 / 124
页数:5
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