Anandamide and other N-acylethanolamines in human tumors

被引：57

作者：

Schmid, PC

Wold, LE

Krebsbach, RJ

Berdyshev, EV

Schmid, HHO

机构：

[1] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA

[2] Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Rochester, MN 55905 USA

来源：

LIPIDS | 2002年 / 37卷 / 09期

关键词：

D O I：

10.1007/s11745-002-0978-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long-chain N-acylethanolamines (NAE), including the endocannabinoid, anandamide, accumulate in mammalian tissues under a variety of pathological conditions. They have also been shown to inhibit the growth of various cancer cell lines in vitro. Here, we report the presence, in widely differing amounts (3.88-254.46 pmol/mumol lipid P), of NAE and their precursor phospholipids in various human tumors and some adjacent unaffected tissues. Anandamide ranged from 1.5 to 48% of total NAE, and incubation of tissue homogenates suggested possible NAE biosynthesis by both the established transacylation-phosphodiesterase pathway via N-acyl PE and by direct N-acylation of ethanolamine.

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收藏

页码：907 / 912

页数：6

相关论文

共 28 条

[1]

BARTLETT GR, 1959, J BIOL CHEM, V234, P466

[2] Stress-induced generation of N-acylethanolamines in mouse epidermal JB6 P+ cells [J].

Berdyshev, EV ;

Schmid, PC ;

Dong, ZG ;

Schmid, HHO .

BIOCHEMICAL JOURNAL, 2000, 346 :369-374

[3] Cannabinoid-receptor-independent cell signalling by N-acylethanolamines [J].

Berdyshev, EV ;

Schmid, PC ;

Krebsbach, RJ ;

Hillard, CJ ;

Huang, CS ;

Chen, NY ;

Dong, ZG ;

Schmid, HHO .

BIOCHEMICAL JOURNAL, 2001, 360 (360) :67-75

[4] Endocannabinoids and fatty acid amides in cancer, inflammation and related disorders [J].

De Petrocellis, L ;

Melck, D ;

Bisogno, T ;

Di Marzo, V .

CHEMISTRY AND PHYSICS OF LIPIDS, 2000, 108 (1-2) :191-209

[5] The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation [J].

De Petrocellis, L ;

Melck, D ;

Palmisano, A ;

Bisogno, T ;

Laezza, C ;

Bifulco, M ;

Di Marzo, V .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) :8375-8380

[6] ISOLATION AND STRUCTURE OF A BRAIN CONSTITUENT THAT BINDS TO THE CANNABINOID RECEPTOR [J].

DEVANE, WA ;

HANUS, L ;

BREUER, A ;

PERTWEE, RG ;

STEVENSON, LA ;

GRIFFIN, G ;

GIBSON, D ;

MANDELBAUM, A ;

ETINGER, A ;

MECHOULAM, R .

SCIENCE, 1992, 258 (5090) :1946-1949

[7] Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells [J].

Di Marzo, V ;

Melck, D ;

Orlando, P ;

Bisogno, T ;

Zagoory, O ;

Bifulco, M ;

Vogel, Z ;

De Petrocellis, L .

BIOCHEMICAL JOURNAL, 2001, 358 (358) :249-255

[8] 'Endocannabinoids' and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance [J].

Di Marzo, V .

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1998, 1392 (2-3) :153-175

[9]

FOLCH J, 1957, J BIOL CHEM, V226, P497

[10] Anti-tumoral action of cannabinoids:: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation [J].

Galve-Roperh, I ;

Sánchez, C ;

Cortés, ML ;

del Pulgar, TG ;

Izquierdo, M ;

Guzmán, M .

NATURE MEDICINE, 2000, 6 (03) :313-319