A glucose-selective fluorescence sensor based on boronic acid-diol recognition

被引：123

作者：

Karnati, VV ^{[1
]}

Gao, XM ^{[1
]}

Gao, SH ^{[1
]}

Yang, WQ ^{[1
]}

Ni, WJ ^{[1
]}

Sankar, S ^{[1
]}

Wang, BH ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 23期

关键词：

D O I：

10.1016/S0960-894X(02)00767-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A glucose selective diphenylboronic acid fluorescent sensor (10a) vith a K-a of 1472 M-1 has been synthesized and evaluated. This sensor shoals a 43- and 49-fold selectivity for glucose over fructose and galactose, respectively. The binding affinity improvement is about 300-fold and the selectivity. improvement for glucose over fructose is about 1400-fold compared vith the monoboronic acid compound. phenylboronic acid. H-1 NMR studies indicate that sensor 10a binds with alpha-D-glucofuranose in a bidentate manner (1:1 ratio). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3373 / 3377

页数：5

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