Myxovirescin analogues via macrocyclic ring-closing metathesis

被引：16

作者：

Content, S ^{[1
]}

Dutton, CJ ^{[1
]}

Roberts, L ^{[1
]}

机构：

[1] Pfizer Ltd, Global Res & Dev, Sandwich CT13 9NJ, Kent, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(02)01024-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A short, efficient route has been developed to analogues of myxovirescin using ring-closing metathesis whereby the antibacterial activity has been retained. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：321 / 325

页数：5

共 24 条

[1] Ruthenium carbene complexes with imidazolin-2-ylidene ligands allow the formation of tetrasubstituted cycloalkenes by RCM [J].

Ackermann, L ;

Fürstner, A ;

Weskamp, T ;

Kohl, FJ ;

Herrmann, WA .

TETRAHEDRON LETTERS, 1999, 40 (26) :4787-4790

[2]

BRENNAN PE, 2001, CHEMTRACTS ORG CHEM, V14, P88

[3] STEREOSPECIFIC TOTAL SYNTHESIS OF A SLOW REACTING SUBSTANCE OF ANAPHYLAXIS, LEUKOTRIENE C-1 [J].

COREY, EJ ;

CLARK, DA ;

GOTO, G ;

MARFAT, A ;

MIOSKOWSKI, C ;

SAMUELSSON, B ;

HAMMARSTROM, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (04) :1436-1439

[4] LEUKOTRIENE-B - TOTAL SYNTHESIS AND ASSIGNMENT OF STEREOCHEMISTRY [J].

COREY, EJ ;

MARFAT, A ;

GOTO, G ;

BRION, F .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (27) :7984-7985

[5] Macrocycles by ring-closing-metathesis, XI:: Syntheses of (R)-(+)-lasiodiplodin, zeranol and truncated salicylihalamides [J].

Fürstner, A ;

Seidel, G ;

Kindler, N .

TETRAHEDRON, 1999, 55 (27) :8215-8230

[6]

GERTH K, 1982, J ANTIBIOT, V35, P1454, DOI 10.7164/antibiotics.35.1454

[7] Recent advances in olefin metathesis and its application in organic synthesis [J].

Grubbs, RH ;

Chang, S .

TETRAHEDRON, 1998, 54 (18) :4413-4450

[8] Olefin metathesis-active ruthenium complexes bearing a nucleophilic carbene ligand [J].

Huang, JK ;

Stevens, ED ;

Nolan, SP ;

Petersen, JL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (12) :2674-2678

[9] THE SYNTHESIS OF 7-CARBONYL HOMOLOGS OF 1-DEOXYNOJIRIMYCIN [J].

KILONDA, A ;

COMPERNOLLE, F ;

TOPPET, S ;

HOORNAERT, GJ .

TETRAHEDRON LETTERS, 1994, 35 (48) :9047-9050

[10] TIN-MEDIATED AND INDIUM-MEDIATED ALLYLATION IN AQUEOUS-MEDIA - APPLICATION TO UNPROTECTED CARBOHYDRATES [J].

KIM, E ;

GORDON, DM ;

SCHMID, W ;

WHITESIDES, GM .

JOURNAL OF ORGANIC CHEMISTRY, 1993, 58 (20) :5500-5507

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