The genetic basis of dyslexia

被引：56

作者：

Francks, C ^{[1
]}

MacPhie, IL ^{[1
]}

Monaco, AP ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust, Ctr Human Genet, Oxford OX3 7BN, England

来源：

LANCET NEUROLOGY | 2002年 / 1卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S1474-4422(02)00221-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dyslexia, a disorder of reading and spelling, is a heterogeneous neurological syndrome with a complex genetic and environmental aetiology. People with dyslexia differ in their individual profiles across a range of cognitive, physiological, and behavioural measures related to reading disability. Some or all of the subtypes of dyslexia might have partly or wholly distinct genetic causes. An understanding of the role of genetics in dyslexia could help to diagnose and treat susceptible children more effectively and rapidly than is currently possible and in ways that account for their individual disabilities. This knowledge will also give new insights into the neurobiology of reading and language cognition. Genetic linkage analysis has identified regions of the genome that might harbour inherited variants that cause reading disability. In particular, loci on chromosomes 6 and 18 have shown strong and replicable effects on reading abilities. These genomic regions contain tens or hundreds of candidate genes, and studies aimed at the identification of the specific causal genetic variants are underway.

引用

页码：483 / 490

页数：8

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