Epitope dominance, competition and T cell affinity maturation

被引：187

作者：

Kedl, RM

Kappler, JW

Marrack, P

机构：

[1] Univ Colorado, Ctr Hlth Sci, Howard Hughes Med Inst, Denver, CO 80206 USA

[2] Univ Colorado, Ctr Hlth Sci, Dept Immunol, Denver, CO 80206 USA

[3] Univ Colorado, Ctr Hlth Sci, Natl Jewish Med & Res Ctr, Denver, CO 80206 USA

[4] Univ Colorado, Ctr Hlth Sci, Dept Biochem & Mol Genet, Denver, CO 80206 USA

[5] Univ Colorado, Ctr Hlth Sci, Dept Pharmacol, Denver, CO 80206 USA

[6] Univ Colorado, Ctr Hlth Sci, Dept Med, Denver, CO 80206 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2003年 / 15卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(02)00009-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Competition for limited resources is a common theme throughout nature, and immunology is no exception. Competition between T cells has been observed in one form or another for a number of decades. Recent advances have allowed the detection of multiple populations of T cells specific for either the same or disparate antigens during a response to a common stimuli. The interplay of these populations of cells dictates both the quality and quantity of the overall T cell response in the host.

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收藏

页码：120 / 127

页数：8

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