Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding

被引：146

作者：

Krantz, BA

Mayne, L

Rumbley, J

Englander, SW

Sosnick, TR

机构：

[1] Univ Penn, Dept Biochem & Biophys, Johnson Res Fdn, Philadelphia, PA 19104 USA

[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

[3] Univ Chicago, Inst Biophys Dynam, Chicago, IL 60637 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2002年 / 324卷 / 02期

基金：

美国国家卫生研究院;

关键词：

protein folding; barriers in protein folding; intermediates in protein folding; burst phase; initial barrier hypothesis;

D O I：

10.1016/S0022-2836(02)01029-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Do stable intermediates form very early in the protein folding process? New results and a quantity of literature that bear on this issue are examined here. Results available provide little support for early intermediate accumulation before an initial search-dependent nucleation barrier. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：359 / 371

页数：13

相关论文

共 68 条

[1] Conformational landscape of cytochrome c folding studied by microsecond-resolved small-angle x-ray scattering [J].

Akiyama, S ;

Takahashi, S ;

Kimura, T ;

Ishimori, K ;

Morishima, I ;

Nishikawa, Y ;

Fujisawa, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (03) :1329-1334

[2]

Akiyama S, 2000, NAT STRUCT BIOL, V7, P514

[3] KINETIC-ANALYSIS OF FOLDING AND UNFOLDING THE 56-AMINO ACID IGG-BINDING DOMAIN OF STREPTOCOCCAL PROTEIN-G [J].

ALEXANDER, P ;

ORBAN, J ;

BRYAN, P .

BIOCHEMISTRY, 1992, 31 (32) :7243-7248

[4] HYDROGEN-BOND STRENGTH AND BETA-SHEET PROPENSITIES - THE ROLE OF A SIDE-CHAIN BLOCKING EFFECT [J].

BAI, YW ;

ENGLANDER, SW .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1994, 18 (03) :262-266

[5] PRIMARY STRUCTURE EFFECTS ON PEPTIDE GROUP HYDROGEN-EXCHANGE [J].

BAI, YW ;

MILNE, JS ;

MAYNE, L ;

ENGLANDER, SW .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1993, 17 (01) :75-86

[6]

Bhuyan AK, 1999, INT CONGR SER, V1194, P261

[7]

BHUYAN AK, 1999, PERSPECTIVES STRUCTU, P295

[8] Origin of apparent fast and non-exponential kinetics of lysozyme folding measured in pulsed hydrogen exchange experiments [J].

Bieri, O ;

Kiefhaber, T .

JOURNAL OF MOLECULAR BIOLOGY, 2001, 310 (04) :919-935

[9] A salt-induced kinetic intermediate is on a new parallel pathway of lysozyme folding [J].

Bieri, O ;

Wildegger, G ;

Bachmann, A ;

Wagner, C ;

Kiefhaber, T .

BIOCHEMISTRY, 1999, 38 (38) :12460-12470

[10] Reaction coordinates of biomolecular isomerization [J].

Bolhuis, PG ;

Dellago, C ;

Chandler, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :5877-5882

← 1 2 3 4 5 6 7 →