Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro

被引：43

作者：

Skinner-Adams, T. S. ^{[1
]}

Andrews, K. T.

Melville, L.

McCarthy, J.

Gardiner, D. L.

机构：

[1] Queensland Inst Med Res, Malaria Biol Lab, Infect Dis & Immunol Div, Herston, Qld 4029, Australia

[2] Australian Ctr Int & Trop Hlth & Nutr, Herston, Qld 4029, Australia

[3] Univ Queensland, Dept Med, Cent Clin Div, Brisbane, Qld 4072, Australia

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 02期

关键词：

D O I：

10.1128/AAC.00840-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.

引用

收藏

页码：759 / 762

页数：4

相关论文

共 22 条

[1] Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria [J].

Andrews, KT ;

Fairlie, DP ;

Madala, PK ;

Ray, J ;

Wyatt, DM ;

Hilton, PM ;

Melville, LA ;

Beattie, L ;

Gardiner, DL ;

Reid, RC ;

Stoermer, MJ ;

Skinner-Adams, T ;

Berry, C ;

McCarthy, JS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (02) :639-648

[2] PLASMODIUM-FALCIPARUM - DIFFERENTIAL SENSITIVITY INVITRO TO E-64 (CYSTEINE PROTEASE INHIBITOR) AND PEPSTATIN-A (ASPARTYL PROTEASE INHIBITOR) [J].

BAILLY, E ;

JAMBOU, R ;

SAVEL, J ;

JAUREGUIBERRY, G .

JOURNAL OF PROTOZOOLOGY, 1992, 39 (05) :593-599

[3] Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine [J].

Banerjee, R ;

Liu, J ;

Beatty, W ;

Pelosof, L ;

Klemba, M ;

Goldberg, DE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :990-995

[4] METHOD FOR TESTING FOR SYNERGY WITH ANY NUMBER OF AGENTS [J].

BERENBAUM, MC .

JOURNAL OF INFECTIOUS DISEASES, 1978, 137 (02) :122-130

[5] INTERACTIONS OF ATOVAQUONE WITH OTHER ANTIMALARIAL-DRUGS AGAINST PLASMODIUM-FALCIPARUM IN-VITRO [J].

CANFIELD, CJ ;

PUDNEY, M ;

GUTTERIDGE, WE .

EXPERIMENTAL PARASITOLOGY, 1995, 80 (03) :373-381

[6] Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum [J].

Duraisingh, MT ;

Roper, C ;

Walliker, D ;

Warhurst, DC .

MOLECULAR MICROBIOLOGY, 2000, 36 (04) :955-961

[7] Contribution of the pfmdr1 gene to antimalarial drug-resistance [J].

Duraisingh, MT ;

Cowman, AF .

ACTA TROPICA, 2005, 94 (03) :181-190

[8] Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites -: Target for the antimalarial activity of bestatin [J].

Gardiner, DL ;

Trenholme, KR ;

Adams, TSS ;

Stack, CM ;

Dalton, JP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (03) :1741-1745

[9] Excess haemoglobin digestion by malaria parasites: a strategy to prevent premature host cell lysis [J].

Lew, VL ;

Macdonald, L ;

Ginsburg, H ;

Krugliak, M ;

Tiffert, T .

BLOOD CELLS MOLECULES AND DISEASES, 2004, 32 (03) :353-359

[10]

LI GD, 2006, MED HYPOTHESES