Autocrine growth effect of IL-8 and GROα on a human pancreatic cancer cell line, Capan-1

被引：124

作者：

Takamori, H

Oades, ZG

Hoch, RC

Burger, M

Schraufstatter, IU

机构：

[1] Kumamoto Univ, Sch Med, Dept Surg 1, Kumamoto 8608556, Japan

[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

[3] La Jolla Inst Expt Med, La Jolla, CA 92037 USA

来源：

PANCREAS | 2000年 / 21卷 / 01期

关键词：

pancreatic cancer; IL-8; GRO alpha; CXCR2;

D O I：

10.1097/00006676-200007000-00051

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A human pancreatic cancer cell line, Capan-1, secretes the chemokines interleukin-8 (IL-8) and growth-related oncogene alpha (GRO alpha). Capan-1 cells also express the chemokine receptor 2 (CXCR2), which is a Gi alpha-protein coupled receptor. Growth of Capan-1 cells was inhibited when anti-IL-8 or anti-GRO alpha monoclonal antibody was added into the culture medium. Pertussis toxin, which blocks Gi alpha. also demonstrated a growth-inhibitory effect on Capan-1 cells. These results indicated that IL-8 and GR alpha act on Capan-1 cells as growth factors in an autocrine manner through CXCR2.

引用

页码：52 / 56

页数：5

共 19 条

[1] FUNCTIONAL DIVERSITY OF GRO GENE-EXPRESSION IN HUMAN-FIBROBLASTS AND MAMMARY EPITHELIAL-CELLS [J].