Diacylglycerol kinases as sources of phosphatidic acid

被引：70

作者：

Cai, Jinjin ^{[1
,2
]}

Abramovici, Hanan ^{[4
,5
]}

Gee, Stephen H. ^{[4
,5
]}

Topham, Matthew K. ^{[1
,2
,3
]}

机构：

[1] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[2] Univ Utah, Dept Oncol Sci, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Internal Med, Salt Lake City, UT 84112 USA

[4] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada

[5] Univ Ottawa, Ctr Neuromuscular Dis, Ottawa, ON K1H 8M5, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2009年 / 1791卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Diacylglycerol kinase; Diacylglycerol; Phosphatidic acid; Phosphatidylinositol; Lipid signaling; PLECKSTRIN HOMOLOGY DOMAIN; BIOLOGICALLY-ACTIVE LIPIDS; PROMOTING PHORBOL ESTERS; CYSTEINE-RICH DOMAINS; T-CELL ANERGY; PROTEIN-KINASE; MOLECULAR-CLONING; RETINAL DEGENERATION; ARABIDOPSIS-THALIANA; NUCLEAR-LOCALIZATION;

D O I：

10.1016/j.bbalip.2009.02.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly apparent that DGKs also influence signaling events through their product, phosphatidic acid (PA). They do so in some cases by associating with proteins and then modifying their activity by generating PA. In other cases, DGKs broadly regulate signaling events by virtue of their ability to provide PA for the synthesis of phosphatidylinositols (PtdIns). (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：942 / 948

页数：7

共 93 条

[1] Diacylglycerol kinase-ζ localization in skeletal muscle is regulated by phosphorylation and interaction with syntrophins [J].

Abramovici, H ;

Hogan, AB ;

Obagi, C ;

Topham, MK ;

Gee, SH .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (11) :4499-4511

[2]

ABRAMOVICI H, MOL BIOL CE IN PRESS

[3] Cardiac-specific overexpression of diacylglycerol kinase ξ prevents Gq protein-coupled receptor agonist-induced cardiac hypertrophy in transgenic mice [J].

Arimoto, T ;

Takeishi, Y ;

Takahashi, H ;

Shishido, T ;

Niizeki, T ;

Koyama, Y ;

Shiga, R ;

Nozaki, N ;

Nakajima, O ;

Nishimaru, K ;

Abe, J ;

Walsh, RA ;

Goto, K ;

Kubota, I .

CIRCULATION, 2006, 113 (01) :60-66

[4] Escherichia coli diacylglycerol kinase is an evolutionarily optimized membrane enzyme and catalyzes direct phosphoryl transfer [J].

Badola, P ;

Sanders, CR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (39) :24176-24182

[5] A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells [J].

Bektas, M ;

Payne, SG ;

Liu, H ;

Goparaju, S ;

Milstien, S ;

Spiegel, S .

JOURNAL OF CELL BIOLOGY, 2005, 169 (05) :801-811

[6] ISOLATION OF A PUTATIVE PHOSPHOLIPASE-C GENE OF DROSOPHILA, NORPA, AND ITS ROLE IN PHOTOTRANSDUCTION [J].

BLOOMQUIST, BT ;

SHORTRIDGE, RD ;

SCHNEUWLY, S ;

PERDEW, M ;

MONTELL, C ;

STELLER, H ;

RUBIN, G ;

PAK, WL .

CELL, 1988, 54 (05) :723-733

[7] A GTPase-independent mechanism of p21-activated kinase activation - Regulation by sphingosine and other biologically active lipids [J].

Bokoch, GM ;

Reilly, AM ;

Daniels, RH ;

King, CC ;

Olivera, A ;

Spiegel, S ;

Knaus, UG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (14) :8137-8144

[8] Molecular cloning and characterization of a novel human diacylglycerol kinase zeta [J].

Bunting, M ;

Tang, W ;

Zimmerman, GA ;

McIntyre, TM ;

Prescott, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (17) :10230-10236

[9] Diacylglycerol kinase-α mediates hepatocyte growth factor-induced epithelial cell scatter by regulating Rac activation and membrane ruffling [J].

Chianale, Federica ;

Cutrupi, Santina ;

Rainero, Elena ;

Baldanzi, Gianluca ;

Porporato, Paolo E. ;

Traini, Sara ;

Filigheddu, Nicoletta ;

Gnocchi, Viola F. ;

Santoro, Massimo M. ;

Parolini, Ornella ;

van Blitterswijk, Wim J. ;

Sinigaglia, Fabiola ;

Graziani, Andrea .

MOLECULAR BIOLOGY OF THE CELL, 2007, 18 (12) :4859-4871

[10]

CHUANG TH, 1993, J BIOL CHEM, V268, P26206

← 1 2 3 4 5 6 7 8 9 10 →