Restricted feeding schedules phase shift daily rhythms of c-Fos and protein Per1 immunoreactivity in corticolimbic regions in rats

被引:116
作者
Angeles-Castellanos, M.
Mendoza, J.
Escobar, C.
机构
[1] Univ Nacl Autonoma Mexico, Fac Med, Dept Anat, Mexico City 04510, DF, Mexico
[2] ULP, CNRS, IFR Neurosci, Strasbourg, France
[3] Univ Veracruzana, Direcc Gen Invest, Xalapa, Veracruz, Mexico
关键词
food-entrainment; c-Fos; limbic system; circadian; motivation;
D O I
10.1016/j.neuroscience.2006.08.064
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Entrainment by daily restricted feeding schedules (RFS) produces food anticipatory activity (FAA) which involves motivational processes which may be regulated by corticolimbic structures and the nucleus accumbens. The present study aimed first to determine whether corticolimbic structures participate in the expression of FAA, therefore c-Fos immunoreactivity (Fos-IR) was employed as marker of neuronal activity. The second goal was to characterize diurnal rhythms of the clock protein protein Perl (PERI) in corticolimbic structures and to determine the influence of RFS on the diurnal temporal pattern. Rats were maintained under RFS with food access for 2 h daily, a control group was fed ad libitum. Food entrainment produced a pattern of increased Fos-IR during FAA and after mealtime in the two sub-regions of the nucleus accumbens (ACC), in the basolateral and central amygdala, in the bed nucleus of the stria terminalis (BNST), in the lateral septum (LS), in the prefrontal cortex (PFC), and in the paraventricular thalamic nucleus (PVT). No increased Fos-IR was observed in the hippocampus. Under ad libitum conditions all structures studied showed daily oscillations of PER1, excluding both amygdalar nuclei and the PFC. RFS shifted and set the daily peaks at zeitgeber time (ZT) 12 for both sub-regions in the accumbens, the hippocampus, lateral septum and PFC. RFS enhanced the amplitude at ZT12 of the BNST and shifted the peak of the PVT to ZT6. No changes were observed in the amygdalar nuclei. Present data indicate that cellular activation of corticolimbic structures is associated with behavioral events related to food anticipatory activity and that mealtime is a relevant signal that shifts daily oscillations of PER1 in corticolimbic structures. Data suggest a relevant role of corticolimbic structures as oscillators for FAA. (c) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:344 / 355
页数:12
相关论文
共 69 条
[1]   ANTICIPATORY ACTIVITY AND ENTRAINMENT OF CIRCADIAN-RHYTHMS IN SYRIAN-HAMSTERS EXPOSED TO RESTRICTED PALATABLE DIETS [J].
ABE, H ;
RUSAK, B .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01) :R116-R124
[2]   Circadian rhythms in isolated brain regions [J].
Abe, M ;
Herzog, ED ;
Yamazaki, S ;
Straume, M ;
Tei, H ;
Sakaki, Y ;
Menaker, M ;
Block, GD .
JOURNAL OF NEUROSCIENCE, 2002, 22 (01) :350-356
[3]  
Ahn S, 2002, J NEUROSCI, V22, P10958
[4]   A circadian rhythm in the expression of PERIOD2 protein reveals a novel SCN-controlled oscillator in the oval nucleus of the bed nucleus of the stria terminalis [J].
Amir, S ;
Lamont, EW ;
Robinson, B ;
Stewart, J .
JOURNAL OF NEUROSCIENCE, 2004, 24 (04) :781-790
[5]   Food entrainment modifies the c-Fos expression pattern in brain stem nuclei of rats [J].
Angeles-Castellanos, M ;
Mendoza, J ;
Díaz-Muñoz, M ;
Escobar, C .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2005, 288 (03) :R678-R684
[6]   c-Fos expression in hypothalamic nuclei of food-entrained rats [J].
Angeles-Castellanos, M ;
Aguilar-Roblero, R ;
Escobar, C .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 286 (01) :R158-R165
[7]   Resetting of circadian time peripheral tissues by glucocorticoid signaling [J].
Balsalobre, A ;
Brown, SA ;
Marcacci, L ;
Tronche, F ;
Kellendonk, C ;
Reichardt, HM ;
Schütz, G ;
Schibler, U .
SCIENCE, 2000, 289 (5488) :2344-2347
[8]   A serum shock induces circadian gene expression in mammalian tissue culture cells [J].
Balsalobre, A ;
Damiola, F ;
Schibler, U .
CELL, 1998, 93 (06) :929-937
[9]   Parsing reward [J].
Berridge, KC ;
Robinson, TE .
TRENDS IN NEUROSCIENCES, 2003, 26 (09) :507-513
[10]   Mind versus metabolism in the control of food intake and energy balance [J].
Berthoud, HR .
PHYSIOLOGY & BEHAVIOR, 2004, 81 (05) :781-793